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Genomic features that predict allelic imbalance in humans suggest patterns of constraint on gene expression variation

Molecular Biology and Evolution

Jun 10, 2009

J TungGregory A Wray

Abstract

Variation in gene expression is an important contributor to phenotypic diversity within and between species. Although this variation often has a genetic component, identification of the genetic variants driving this relationship remains challenging. In particular, measurements of gene e...read more

Mentioned in this Paper

Genome
Candidate Disease Gene
Gene Expression
Cell Differentiation Process
Genomics
Genes, vif
Cistron
Alleles
Genetic Polymorphism
Negative Selection
Paper Details
References
  • References70
  • Citations5
12345...
  • References70
  • Citations5
1

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Genomic features that predict allelic imbalance in humans suggest patterns of constraint on gene expression variation

Molecular Biology and Evolution

Jun 10, 2009

J TungGregory A Wray

PMID: 19506001

DOI: 10.1093/molbev/msp113

Abstract

Variation in gene expression is an important contributor to phenotypic diversity within and between species. Although this variation often has a genetic component, identification of the genetic variants driving this relationship remains challenging. In particular, measurements of gene e...read more

Mentioned in this Paper

Genome
Candidate Disease Gene
Gene Expression
Cell Differentiation Process
Genomics
Genes, vif
Cistron
Alleles
Genetic Polymorphism
Negative Selection

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Human Vascular Endothelial Cell Atlas: Young & Old

Examining the genomics, transcriptomics, proteomics and metabolomics of the human vascular endothelial cells at the single cell level will help build a single cell atlas of human vascular endothelium, which would give a unique ID card for each cell type, a three-dimensional map of how cell types work together to form tissues and insights into how changes in the map underlie health and disease of the vascular endothelium from young to old age. Disocver the latest research on the single cell atlas of human vascular endothelial cell atlas here.

Related Papers

Molecular Ecology

Allele-specific gene expression in a wild nonhuman primate population

Molecular EcologyJanuary 14, 2011
J TungSusan C Alberts
Paper Details
References
  • References70
  • Citations5
12345...
  • References70
  • Citations5
1

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