Genomic Heterogeneity and the Small Renal Mass

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Daiki UenoBrian Shuch

Abstract

Purpose: Tumor heterogeneity may represent a barrier to preoperative genomic characterization by needle biopsy in clear cell renal cell carcinoma (ccRCC). The extent of heterogeneity in small renal tumors remains unknown. Therefore, we set out to evaluate heterogeneity in resected large and small renal tumors.Experimental Design: We conducted a study from 2013 to 2016 that evaluated 47 consecutive ccRCC tumors resected during radical or partial nephrectomy. Cases were designated as small (<4 cm) and large (>7 cm) tumors. Each tumor had three regions sampled. Copy-number variation (CNV) was assessed and gene expression analysis was performed to characterize the clear-cell A and B (ccA/ccB) profile and the cell-cycle progression (CCP) score. Genomic heterogeneity between three regions was evaluated using CNV subclonal events, regional expression profiles, and correlation between gene expression.Results: Twenty-three small and 24 large tumors were analyzed. Total CNVs and subclonal CNVs events were less frequent in small tumors (P < 0.001). Significant gene expression heterogeneity was observed for both CCP scores and ccA/ccB classifications. Larger tumors had more variance in CCP scores (P = 0.026). The distribution of ccA/ccB di...Continue Reading

References

Dec 1, 1995·Radiology·M A BosniakJ Waisman
Nov 28, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Amnon ZismanArie S Belldegrun
Sep 21, 2006·Journal of the National Cancer Institute·John M HollingsworthBrent K Hollenbeck
May 21, 2008·Cancer·Christopher J KanePeter R Carroll
Apr 24, 2010·Journal of the National Cancer Institute·H Gilbert Welch, William C Black
Jan 12, 2011·Nature Biotechnology·James T RobinsonJill P Mesirov
Mar 9, 2012·The New England Journal of Medicine·Marco GerlingerCharles Swanton
Jun 25, 2013·Nature·UNKNOWN Cancer Genome Atlas Research Network
Sep 10, 2013·The Journal of Urology·Brian ShuchUNKNOWN Urologic Diseases in America Project
Mar 13, 2014·European Urology·Samira A BrooksW Kimryn Rathmell
Jun 25, 2014·The Journal of Urology·Mark W BallMohamad E Allaf
Jan 15, 2015·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Benoit BeuselinckJessica Zucman-Rossi
Apr 23, 2015·European Urology·Patrick O RichardAntonio Finelli
Sep 26, 2015·Cancer Biomarkers : Section a of Disease Markers·Eric J AskelandJames A Brown
May 10, 2017·The Journal of Urology·Steven CampbellPhilip M Pierorazio
Jun 10, 2017·Journal of the National Comprehensive Cancer Network : JNCCN·Robert J MotzerRashmi Kumar

❮ Previous
Next ❯

Citations

May 7, 2020·Insights Into Imaging·Carmen SebastiàCarlos Nicolau
Jan 9, 2021·World Journal of Urology·Umberto CapitanioUNKNOWN Kidney Cancer Working Group of the Young Academic Urologists (YAU) Working Party of the European Association of Urology (EAU

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Genomics (Keystone)

Cancer genomics approaches employ high-throughput technologies to identify the complete catalog of somatic alterations that characterize the genome, transcriptome and epigenome of cohorts of tumor samples. Discover the latest research using such technologies in this feed.

Adenocarcinoma, Clear Cell

Clear Cell Adenocarcinoma is a tumor that arises in the female genital tract and is characterized by cells that appear clear under the microscope. Discover the latest research here.