Genomic impact, chromosomal distribution and transcriptional regulation of HERV elements.

Molecules and Cells
Heui-Soo Kim

Abstract

Human endogenous retroviruses (HERVs) mediate structural variation and genomic instability based on their multiple copy number, inherent ability to mobilize via reverse transcriptase, and high sequence similarity. Moreover, they undergo multiple amplification and retrotransposition events, resulting in the widespread distribution of complete or partial retroviral sequences throughout the primate genome. As such, HERV elements have played important biological roles in genome evolution, and their long terminal repeat (LTR) elements contain numerous regulatory sequences, including effective promoters, enhancers, polyadenylation signals, and transcription factorbinding sites. Lastly, HERV elements are capable of influencing the expression of neighboring genes, a process that also contributed to primate evolution.

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Citations

Mar 4, 2014·Computational Biology and Chemistry·Hongqiang LvRuiling Liu
Jun 18, 2015·Cellular and Molecular Life Sciences : CMLS·Maria SuntsovaAnton Buzdin
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Nov 17, 2020·Journal of Molecular Biology·Ina P O'CarrollYun-Xing Wang
Sep 5, 2021·Molecular Biology and Evolution·Lei YangMary Poss

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