Genomic imprinting--defusing the ovarian time bomb

Trends in Genetics : TIG
S Varmuza, M Mann


Why do mammals imprint their parental genomes? Imprinting is seen in many phyla, but that in mammals is by far the most dramatic. Is there something peculiar to mammals that calls for such a striking phenomenon? We propose that imprinting is a device that protects female mammals from the potential ravages of ovarian trophoblast disease. Without imprinting, the ovarian teratomas that frequently arise from parthenogenetically activated oocytes in situ might be capable of forming malignant trophoblast. An allele that favored imprinting would spread rapidly because of the great increase in fitness associated with suppressing a lethal cancer of females.


Feb 22, 1991·Cell·T M DeChiaraA Efstratiadis
Feb 1, 1991·Trends in Genetics : TIG·T Moore, D Haig
Jan 1, 1990·Developmental Genetics·A O Ruvinsky, A I Agulnik
Jan 1, 1988·Annual Review of Genetics·D Solter
Mar 1, 1988·Trends in Genetics : TIG·M A SuraniN D Allen
Nov 25, 1993·Nature·E LiR Jaenisch
Sep 7, 1993·Journal of Theoretical Biology·S Varmuza
Jun 1, 1993·Nature Genetics·A P Feinberg
Apr 22, 1993·Nature·S RainierA P Feinberg
Apr 22, 1993·Nature·A C Ferguson-SmithM A Surani
May 1, 1993·Current Biology : CB·A P Bird
Mar 1, 1993·Current Biology : CB·T Alber
May 1, 1992·Roux's Archives of Developmental Biology : the Official Organ of the EDBO·Susannah Louise Varmuza

❮ Previous
Next ❯


May 20, 1998·Molecular Reproduction and Development·L J HagemannH R Tervit
Sep 6, 2001·Hormones and Behavior·E B Keverne
Oct 12, 2010·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Mary J O'ConnellCharles Spillane
Oct 1, 1994·Trends in Genetics : TIG·D Haig
Jan 1, 1996·Placenta·G C FranklinR Ohlsson
Dec 5, 2000·Trends in Genetics : TIG·F Pardo-Manuel de VillenaC Sapienza
Aug 1, 1997·Trends in Genetics : TIG·R Jaenisch
May 14, 1999·Trends in Ecology & Evolution·H G SpencerM W Feldman
Sep 15, 2000·European Journal of Obstetrics, Gynecology, and Reproductive Biology·K Devriendt
Jan 1, 1997·Bio Systems·R Paton
Aug 2, 2000·Trends in Endocrinology and Metabolism : TEM·M A Preece, G E Moore
May 2, 2007·Journal of Genetics and Genomics = Yi Chuan Xue Bao·Anjana Munshi, Shanti Duvvuri
Jan 26, 2011·Expert Reviews in Molecular Medicine·Santiago Uribe-LewisAdele Murrell
Jan 17, 1995·Proceedings of the National Academy of Sciences of the United States of America·J H Thomas
Oct 21, 2010·Human Reproduction Update·Ewka C M NelissenJohannes L H Evers
Nov 25, 1994·Nucleic Acids Research·C M RubinC W Schmid
Nov 1, 1995·Acta Psychiatrica Scandinavica·M Grigoroiu-SerbanescuV Ardelean
Oct 23, 2003·Annual Review of Cell and Developmental Biology·Raluca I VeronaMarisa S Bartolomei
Jan 1, 1996·Annual Review of Genetics·M Lalande
Jan 1, 1997·Annual Review of Genetics·M S Bartolomei, S M Tilghman
Aug 12, 2005·Cytogenetic and Genome Research·J F McDonaldA J Matzke
Apr 1, 2006·Cytogenetic and Genome Research·S Abu-AmeroG Moore
May 31, 2008·BMC Evolutionary Biology·Eleanor I AgerMarilyn B Renfree
Mar 4, 2000·Environmental Health Perspectives·S K Murphy, R L Jirtle
Nov 24, 2006·PLoS Genetics·Andrew J Wood, Rebecca J Oakey
Jun 20, 2006·Genetics·Hamish G SpencerThomas LoFaro
Sep 27, 2005·Reproduction : the Official Journal of the Society for the Study of Fertility·A K E Swales, N Spears
Jan 9, 2014·Heredity·H G Spencer, A G Clark
Aug 18, 2005·Diagnostic Molecular Pathology : the American Journal of Surgical Pathology, Part B·Hidenori KatoNorio Wake
Aug 2, 2001·The Journal of Experimental Zoology·J K KillianR L Jirtle
Aug 9, 2007·Trends in Genetics : TIG·Timothy A HoreJennifer A Marshall Graves
Sep 2, 2005·Journal of Evolutionary Biology·H G Spencer, M W Feldman
Aug 12, 2006·Clinical and Experimental Dermatology·G W M Millington
Jul 2, 2005·Trends in Genetics : TIG·Ian M MorisonHamish G Spencer
Dec 1, 1995·Differentiation; Research in Biological Diversity·K E Latham
Oct 3, 2015·American Journal of Obstetrics and Gynecology·David Monk
Oct 30, 2013·Biological Reviews of the Cambridge Philosophical Society·Luke Holman, Hanna Kokko
Nov 18, 2003·Annual Review of Genetics·Elena de la Casa-Esperón, Carmen Sapienza
Dec 1, 2004·Annual Review of Genetics·David Haig
Nov 28, 2000·Annual Review of Genetics·H G Spencer

❮ Previous
Next ❯

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Epigenetics Insights from Twin Studies

Find the latest research on epigenetics and twin studies here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.


Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Regulation of Vocal-Motor Plasticity

Dopaminergic projections to the basal ganglia and nucleus accumbens shape the learning and plasticity of motivated behaviors across species including the regulation of vocal-motor plasticity and performance in songbirds. Discover the latest research on the regulation of vocal-motor plasticity here.

Myocardial Stunning

Myocardial stunning is a mechanical dysfunction that persists after reperfusion of previously ischemic tissue in the absence of irreversible damage including myocardial necrosis. Here is the latest research.

© 2021 Meta ULC. All rights reserved