Genomic Imprinting and the Regulation of Postnatal Neurogenesis

Brain Plasticity
Anna Lozano-UreñaSacri R Ferrón

Abstract

Most genes required for mammalian development are expressed from both maternally and paternally inherited chromosomal homologues. However, there are a small number of genes known as "imprinted genes" that only express a single allele from one parent, which is repressed on the gene from the other parent. Imprinted genes are dependent on epigenetic mechanisms such as DNA methylation and post-translational modifications of the DNA-associated histone proteins to establish and maintain their parental identity. In the brain, multiple transcripts have been identified which show parental origin-specific expression biases. However, the mechanistic relationship with canonical imprinting is unknown. Recent studies on the postnatal neurogenic niches raise many intriguing questions concerning the role of genomic imprinting and gene dosage during postnatal neurogenesis, including how imprinted genes operate in concert with signalling cues to contribute to newborn neurons' formation during adulthood. Here we have gathered the current knowledge on the imprinting process in the neurogenic niches. We also review the phenotypes associated with genetic mutations at particular imprinted loci in order to consider the impact of imprinted genes in the...Continue Reading

References

Feb 22, 1991·Cell·T M DeChiaraA Efstratiadis
Oct 21, 1993·Nature·Y HaoB Tycko
Apr 1, 1994·Differentiation; Research in Biological Diversity·K GotoH Kondo
May 1, 1993·Nature Genetics·N GiannoukakisC Polychronakos
Nov 24, 2001·Science·D Bourc'hisT H Bestor
Oct 30, 2003·Nature Neuroscience·Fiona Doetsch
Mar 5, 2004·Human Molecular Genetics·Diana LuciferoJacquetta M Trasler
Sep 24, 2004·Current Opinion in Genetics & Development·Jenny Hsieh, Fred H Gage
Dec 3, 2004·Proceedings of the National Academy of Sciences of the United States of America·Florian T MerkleArturo Alvarez-Buylla
Apr 20, 2005·Placenta·P M CoanA C Ferguson-Smith
Jun 15, 2005·Annual Review of Biochemistry·Mary Grace Goll, Timothy H Bestor
Jul 28, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Bénédicte MennArturo Alvarez-Buylla
Nov 3, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Tobias D MersonAnne K Voss
Dec 21, 2006·The Journal of Pathology·P Jelinic, P Shaw
Jan 16, 2007·Cancer Cell·Christopher CalabreseRichard J Gilbertson
Feb 27, 2007·Cell·M Azim SuraniPetra Hajkova
May 1, 2007·Current Opinion in Cell Biology·Carol A Edwards, Anne C Ferguson-Smith
May 25, 2007·Nature·Adrian Bird
Oct 11, 2007·Nature Reviews. Neuroscience·Lawrence S WilkinsonAnthony R Isles
Mar 14, 2008·The New England Journal of Medicine·Manel Esteller
Jul 16, 2008·American Journal of Medical Genetics. Part a·Bernhard Horsthemke, Joseph Wagstaff
Apr 16, 2009·Proceedings of the Japan Academy. Series B, Physical and Biological Sciences·Susumu OtsukaEiji Nanba
Jun 25, 2009·Journal of Neurochemistry·Hyeon Ju KimDe-Maw Chuang
Jul 11, 2009·Cell Death and Differentiation·B JosephO Hermanson
Feb 26, 2010·Epigenetics & Chromatin·Kirsten R McEwen, Anne C Ferguson-Smith
Nov 16, 2010·Progress in Molecular Biology and Translational Science·Rosemarie Chirco D'Angelo, Max S Wicha
Jan 14, 2011·Cerebral Cortex·Philip GaughwinPatrik Brundin
Mar 9, 2011·Neuron·Maria K LehtinenChristopher A Walsh
Mar 15, 2011·The European Journal of Neuroscience·Jiaqi SunHongjun Song

❮ Previous
Next ❯

Citations

Aug 27, 2019·Movement Disorders : Official Journal of the Movement Disorder Society·Elisa MenozziKailash P Bhatia
Jan 22, 2020·Neurología : publicación oficial de la Sociedad Española de Neurología·L J Reséndiz-CastilloA A Canales-Aguirre
Mar 14, 2021·Proceedings of the National Academy of Sciences of the United States of America·Raquel Montalbán-LoroSacri R Ferrón
Mar 30, 2021·Frontiers in Oncology·Anna Lozano-UreñaSacri R Ferrón

❮ Previous
Next ❯

Methods Mentioned

BETA
histone acetylation

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2022 Meta ULC. All rights reserved