Genomic imprinting in mammals

Annual Review of Genetics
M S Bartolomei, S M Tilghman

Abstract

A handful of autosomal genes in the mammalian genome are inherited in a silent state from one of the two parents, and in a fully active form from the other, thereby rendering the organism functionally hemizygous for imprinted genes. To date 19 imprinted genes have been identified; 5 are expressed from the maternal chromosome while the rest are expressed from the paternal chromosome. Allele-specific methylation of CpG residues, established in one of the germlines and maintained throughout embryogenesis, has been clearly implicated in the maintenance of imprinting in somatic cells. Although the function of imprinting remains a subject of some debate, the process is thought to have an important role in regulating the rate of fetal growth.

References

Jan 1, 1978·Cytogenetics and Cell Genetics·A G Searle, C V Beechey
Jan 17, 1975·Nature·H S Chandra, S W Brown
Apr 1, 1992·Nature Genetics·Y Zhang, B Tycko
Aug 31, 1992·FEBS Letters·J RachmilewitzA Hochberg
Apr 1, 1992·Seminars in Cell Biology·R M Frederickson, N Sonenberg
Jan 1, 1990·Molecular and Cellular Biology·C I BrannanS M Tilghman
May 9, 1991·Nature·M S BartolomeiS M Tilghman
Jan 30, 1990·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·W Doerfler
Feb 22, 1991·Cell·T M DeChiaraA Efstratiadis
Jan 1, 1991·Cytogenetics and Cell Genetics·C V Beechey, A G Searle
Jan 1, 1990·Annual Review of Genetics·E U Selker
Oct 1, 1990·Genetical Research·A G Searle, C V Beechey
Jul 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·G McAllisterM R Lerner
Jan 1, 1988·Annual Review of Genetics·D Solter
Oct 7, 1988·Cell·O R Choi, J D Engel
Apr 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·J M Nickol, G Felsenfeld
Jan 1, 1985·Basic Life Sciences·A G Searle, C V Beechey
Nov 1, 1983·The Journal of Experimental Zoology·J McGrath, D Solter
Sep 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·V PachnisS M Tilghman

❮ Previous
Next ❯

Citations

Sep 25, 1999·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·F Lyko, R Paro
Jul 27, 2000·Journal of Cellular Physiology·S I Grewal
Dec 22, 1999·Genetic Epidemiology·K StrauchM P Baur
Aug 28, 1999·Molecular Biotechnology·J M Greally
Feb 22, 2012·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·Shize LiRunqing Yang
May 22, 2007·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Edwin G PeeryKaren A Johnstone
Apr 29, 2009·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Joaquim CasellasJuan F Medrano
Jun 15, 2007·Human Genetics·Olga Y GorlovaChristopher I Amos
Apr 22, 2005·Apoptosis : an International Journal on Programmed Cell Death·N AndolloJ Aréchaga
Aug 12, 2008·Genetica·Hamish G Spencer
Oct 22, 2009·Journal of Assisted Reproduction and Genetics·Merlin G Butler
Jun 19, 2004·Genomics·Raluca I Verona, Marisa S Bartolomei
Nov 3, 2001·Biochimica Et Biophysica Acta·G J Veenstra, A P Wolffe
Oct 3, 2002·Biochimica Et Biophysica Acta·Yuka YanagisawaKazuo Maruyama
Dec 10, 1999·Diabetes Research and Clinical Practice·H K Lee
Feb 28, 2001·Trends in Genetics : TIG·R OhlssonJ A Graves
Aug 30, 2001·Trends in Genetics : TIG·R OhlssonV Lobanenkov
May 14, 1999·Trends in Ecology & Evolution·H G SpencerM W Feldman
Dec 3, 2002·Archives of Medical Research·Félix Recillas-Targa
Jun 29, 2000·Neurochemistry International·P J Brooks
Sep 5, 2002·Medical Hypotheses·Gilberto N O Brito
Sep 5, 2002·Medical Hypotheses·K SummersM Farwell
Oct 12, 2000·Domestic Animal Endocrinology·P Sellier
Jan 4, 2001·Reproductive Toxicology·S L Beck
Aug 5, 1998·Current Opinion in Genetics & Development·Y JiangA L Beaudet
Feb 7, 2001·Trends in Endocrinology and Metabolism : TEM·J Newell-PriceP King
May 14, 1999·Trends in Endocrinology and Metabolism : TEM·L S Weinstein, S Yu
Apr 3, 2002·Trends in Molecular Medicine·Robert Brown, Gordon Strathdee
Jan 30, 2004·Reproductive Biomedicine Online·Christine Wrenzycki, Heiner Niemann
Oct 17, 1998·Molecular and Cellular Biology·B Hendrich, A Bird
Feb 28, 2014·Journal of Developmental Origins of Health and Disease·M A Hernández-ValeroO Gorlova
Sep 5, 2001·Clinical Genetics·A L DeStefanoF Schwartz
Apr 9, 2005·Nature Reviews. Genetics·Wolf Reik, Annabelle Lewis
Oct 19, 2006·European Journal of Human Genetics : EJHG·C B Santos-Rebouças, M M G Pimentel
Oct 19, 2001·European Journal of Biochemistry·E BallestarP A Wade
Aug 18, 2000·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·K I TatematsuF Ishikawa
Jun 20, 2002·European Journal of Biochemistry·Shotaro KishikawaKazunari K Yokoyama

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Methods Mentioned

BETA
targeted mutation
dissection
transfection
RIP
targeted mutations

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