Genomic incompatibilities in the diploid and tetraploid offspring of the goldfish × common carp cross

Proceedings of the National Academy of Sciences of the United States of America
Shaojun LiuYa-Ping Zhang

Abstract

Polyploidy is much rarer in animals than in plants but it is not known why. The outcome of combining two genomes in vertebrates remains unpredictable, especially because polyploidization seldom shows positive effects and more often results in lethal consequences because viable gametes fail to form during meiosis. Fortunately, the goldfish (maternal) × common carp (paternal) hybrids have reproduced successfully up to generation 22, and this hybrid lineage permits an investigation into the genomics of hybridization and tetraploidization. The first two generations of these hybrids are diploids, and subsequent generations are tetraploids. Liver transcriptomes from four generations and their progenitors reveal chimeric genes (>9%) and mutations of orthologous genes. Characterizations of 18 randomly chosen genes from genomic DNA and cDNA confirm the chimera. Some of the chimeric and differentially expressed genes relate to mutagenesis, repair, and cancer-related pathways in 2nF1. Erroneous DNA excision between homologous parental genes may drive the high percentage of chimeric genes, or even more potential mechanisms may result in this phenomenon. Meanwhile, diploid offspring show paternal-biased expression, yet tetraploids show mate...Continue Reading

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Citations

Sep 2, 2017·Science China. Life Sciences·Jie ChenShaojun Liu
Sep 17, 2018·Journal of Biochemistry·Yoshihiro Omori, Tetsuo Kon
Nov 28, 2019·PLoS Genetics·Anna RunemarkJoana I Meier
Jul 24, 2020·Science China. Life Sciences
Aug 28, 2020·Frontiers in Genetics·Xu HuangShaojun Liu
Dec 17, 2018·Science China. Life Sciences·Shi WangShaojun Liu
Aug 7, 2018·Frontiers in Genetics·Fanqian YinJing Luo
Jun 18, 2020·Science China. Life Sciences·Zhuangwen MaoShaojun Liu
Nov 4, 2020·Proceedings of the National Academy of Sciences of the United States of America·Duo ChenJisen Zhang
Jun 22, 2021·Frontiers in Physiology·Wen-Bin LiuYa-Mei Xiao
Jul 21, 2021·Genetica·Takahiro MurakamiKazuki Sato
Aug 31, 2021·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Ning-Xia XiongShao-Jun Liu

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