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Genomic landscape and chronological reconstruction of driver events in multiple myeloma

Nature Communications

Aug 23, 2019

Francesco MauraPeter J. Campbell

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Abstract

The multiple myeloma (MM) genome is heterogeneous and evolves through preclinical and post-diagnosis phases. Here we report a catalog and hierarchy of driver lesions using sequences from 67 MM genomes serially collected from 30 patients together with public exome datasets. Bayesian clus...read more

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Chromosomes
Biological Evolution
Gene Duplication
Genome
Multiple Myeloma
Virus Replication
Shapes
Reconstructive Surgical Procedures
Structure
Drivers of Vehicles
18
50
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Genomic landscape and chronological reconstruction of driver events in multiple myeloma

Nature Communications

Aug 23, 2019

Francesco MauraPeter J. Campbell

PMID: 31444325

DOI: 10.1038/s41467-019-11680-1

Abstract

The multiple myeloma (MM) genome is heterogeneous and evolves through preclinical and post-diagnosis phases. Here we report a catalog and hierarchy of driver lesions using sequences from 67 MM genomes serially collected from 30 patients together with public exome datasets. Bayesian clus...read more

Mentioned in this Paper

Chromosomes
Biological Evolution
Gene Duplication
Genome
Multiple Myeloma
18
50

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