Genomic landscape and prognostic analysis of mantle cell lymphoma

Cancer Gene Therapy
Ping YangHongmei Jing

Abstract

To gain insight into the molecular pathogenesis of patients with mantle cell lymphoma (MCL), next-generation whole-exome sequencing of 16 MCL patients was performed. We identified recurrent mutations in genes that are well known to be functionally relevant in MCL, including ATM (37.5%), TP53 (31.3%), WHSC1 (31.3%), CCND1 (18.8%), NOTCH2 (6.3%), and CDKN2A (6.3%). We also identified somatic mutations in genes for which a functional role in MCL has not been previously suspected. These genes included CCDC15, APC, CDH1, S1PR1, ATRX, BRCA2, CASP8, and NOTCH3. Further, we investigated the prognostic factors associated with MCL from clinical, pathological, and genetic mutations. Mutations of TP53 (P = 0.021) was a significant prognostic factor with shorter overall survival (OS). Although there was no statistical difference, the median survival time of patients with WHSC1 mutations was shorter than those without mutations (P = 0.070). Mutations in ATM and CCND1 had no prognostic value (P = 0.552, 0.566). When adjusted for MCL International Prognostic Index (MIPI) or combined MCL-International Prognostic Index (MIPI-c), TP53 and WHSC1 mutations were the most important prognostic factors in MCL (P < 0.05). Our data provide an unbiased vi...Continue Reading

References

May 16, 2002·The Journal of Biological Chemistry·Sarah Spiegel, Sheldon Milstien
Oct 27, 2007·Blood·Eva HosterUNKNOWN European Mantle Cell Lymphoma Network
Apr 16, 2008·British Journal of Haematology·Pedro Jares, Elías Campo
Jun 27, 2009·Blood·Michele Ghielmini, Emanuele Zucca
Jan 19, 2010·Bioinformatics·Heng Li, Richard Durbin
Jul 2, 2011·Leukemia·A M HalldórsdóttirR Rosenquist
Feb 22, 2012·Proceedings of the National Academy of Sciences of the United States of America·Jens G LohrTodd R Golub
Oct 2, 2012·The Journal of Clinical Investigation·Pedro JaresElias Campo
Apr 9, 2013·Handbook of Experimental Pharmacology·Shanmugam Panneer Selvam, Besim Ogretmen
Oct 23, 2013·Proceedings of the National Academy of Sciences of the United States of America·Sílvia BeàElías Campo
Apr 26, 2014·Annals of Hematology·Christophe LeuxAlain Monnereau
Oct 11, 2014·International Journal of Cancer. Journal International Du Cancer·Francesco MorraAngela Celetti
Dec 4, 2014·The Breast : Official Journal of the European Society of Mastology·Esther Molina-MontesMaría-José Sánchez
Jan 30, 2015·Nature·UNKNOWN Cancer Genome Atlas Network
May 29, 2015·American Journal of Hematology·Charles HerbauxUNKNOWN GFM (Groupe Francophone des Myelodysplasies)
May 30, 2015·Blood·Marie-Hélène Delfau-LarueUNKNOWN European Mantle Cell Lymphoma Network
Jan 13, 2016·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Chan Yoon CheahMichael L Wang
Mar 2, 2016·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Eva HosterWolfram Klapper
Jul 28, 2016·Oncotarget·Makhdum AhmedMichael Wang
Mar 3, 2017·BMC Bioinformatics·Antonio FabregatHenning Hermjakob
Apr 11, 2017·Clinical Epigenetics·Yashna PaulKumaravel Somasundaram
Jun 21, 2017·JAMA : the Journal of the American Medical Association·Karoline B KuchenbaeckerHåkan Olsson

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Citations

Sep 11, 2019·International Journal of Molecular Sciences·Pavel Klener
Jun 18, 2020·Cancers·Gaël Roué, Brigitte Sola
Aug 28, 2020·Expert Opinion on Therapeutic Targets·Pavel Klener
Oct 5, 2018·Oncology Research and Treatment·Anna SchmittH Christian Reinhardt
Apr 10, 2019·American Journal of Hematology·Preetesh Jain, Michael Wang
Oct 20, 2020·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Preetesh JainMichael Wang
Apr 21, 2019·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Dana PrukovaPavel Klener
Jan 29, 2021·Current Hematologic Malignancy Reports·Edward NabrinskyPaul B Koller
Aug 31, 2020·Hematology/oncology Clinics of North America·Kevin WangSelina Chen-Kiang
Aug 31, 2020·Hematology/oncology Clinics of North America·Thomas D Rodgers, Jonathan W Friedberg
Mar 31, 2021·British Journal of Haematology·Elisabeth SilkenstedtMartin Dreyling
Jul 15, 2021·Experimental Hematology & Oncology·Panruo JiangHaige Ye

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Methods Mentioned

BETA
biopsies
PCR
cytogenetic aberration

Software Mentioned

Reactome
ANNOVAR
BWA
Integrated Genomics Viewer ( IGV
GATK Best Practices pipeline
FastQC
GATK
VarScan

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