Genomic landscapes of endogenous retroviruses unveil intricate genetics of conventional and genetically-engineered laboratory mouse strains

Experimental and Molecular Pathology
Kang-Hoon LeeKiho Cho

Abstract

Laboratory strains of mice, both conventional and genetically engineered, have been introduced as critical components of a broad range of studies investigating normal and disease biology. Currently, the genetic identity of laboratory mice is primarily confirmed by surveying polymorphisms in selected sets of "conventional" genes and/or microsatellites in the absence of a single completely sequenced mouse genome. First, we examined variations in the genomic landscapes of transposable repetitive elements, named the TREome, in conventional and genetically engineered mouse strains using murine leukemia virus-type endogenous retroviruses (MLV-ERVs) as a probe. A survey of the genomes from 56 conventional strains revealed strain-specific TREome landscapes, and certain families (e.g., C57BL) of strains were discernible with defined patterns. Interestingly, the TREome landscapes of C3H/HeJ (toll-like receptor-4 [TLR4] mutant) inbred mice were different from its control C3H/HeOuJ (TLR4 wild-type) strain. In addition, a CD14 knock-out strain had a distinct TREome landscape compared to its control/backcross C57BL/6J strain. Second, an examination of superantigen (SAg, a "TREome gene") coding sequences of mouse mammary tumor virus-type ERVs...Continue Reading

References

Jun 1, 1997·Mammalian Genome : Official Journal of the International Mammalian Genome Society·D W ThreadgillT Magnuson
Sep 1, 1997·Molecular and Cellular Biology·K Weichman, J R Chaillet
Feb 19, 2000·Current Opinion in Immunology·B Beutler
Dec 6, 2002·Nature·UNKNOWN Mouse Genome Sequencing ConsortiumEric S Lander
Jan 30, 2004·Trends in Genetics : TIG·Eunju SeongMargit Burmeister
Sep 2, 2004·Nature Genetics·Christopher P AustinBrian Zambrowicz
Oct 7, 2004·Genome Research·Folami Y IderaabdullahFernando Pardo-Manuel de Villena
Sep 30, 2006·Trends in Genetics : TIG·Robert A TaftMichael V Wiles
Feb 28, 2007·Human Mutation·Belinda GiardineRoss C Hardison
Feb 12, 2008·Trends in Genetics : TIG·Elaine R Mardis
Feb 23, 2008·Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology·Astrid BöhneJean-Nicolas Volff
Mar 5, 2008·Shock·Kiho ChoDavid G Greenhalgh
Jun 10, 2008·Experimental and Molecular Pathology·Kristen S YeeDavid G Greenhalgh
Sep 30, 2008·Brain, Behavior, and Immunity·Amy F Eisener-DormanValerie J Bolivar
May 19, 2009·Experimental Animals·Kazuyuki MekadaAtsushi Yoshiki
Mar 10, 2012·Frontiers in Genetics·Wenbo Mu, Wei Zhang
May 3, 2012·Experimental and Molecular Pathology·Kang-Hoon LeeKiho Cho
Jan 30, 2013·Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology·Kang-Hoon LeeKiho Cho
Feb 13, 2013·Proceedings of the National Academy of Sciences of the United States of America·Junhee SeokUNKNOWN Inflammation and Host Response to Injury, Large Scale Collaborative Research Program
Aug 10, 2013·Nature Biotechnology·Dali LiMingyao Liu
Oct 3, 2013·Nature Cell Biology·Janet Rossant
Oct 10, 2013·Nature Reviews. Molecular Cell Biology·Sarah Geisler, Jeff Coller
Feb 11, 2014·Experimental and Molecular Pathology·Kang-Hoon LeeKiho Cho
Aug 6, 2014·Proceedings of the National Academy of Sciences of the United States of America·Keizo Takao, Tsuyoshi Miyakawa
Feb 19, 2015·Proceedings of the National Academy of Sciences of the United States of America
Apr 4, 2015·Experimental and Molecular Pathology·Kang-Hoon LeeKiho Cho

❮ Previous
Next ❯

Citations

Dec 9, 2020·Annual Review of Animal Biosciences·Elliott S Chiu, Sue VandeWoude

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.