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Genomic meta-analysis of the interplay between 3D chromatin organization and gene expression programs under basal and stress conditions

Epigenetics & Chromatin

Aug 31, 2018

Idan NurickRan Elkon

Abstract

Our appreciation of the critical role of the genome's 3D organization in gene regulation is steadily increasing. Recent 3C-based deep sequencing techniques elucidated a hierarchy of structures that underlie the spatial organization of the genome in the nucleus. At the top of this hierar...read more

Mentioned in this Paper

Meta-Analysis (Publications)
Nucleic Acid Sequence Based Analysis
Meta Analysis (Statistical Procedure)
Invariant Natural Killer T-Cells
Genome
Three-dimensional
Regulation of Biological Process
Transcription, Genetic
Tissue-Specific Gene Expression
Promoter
4
33
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Genomic meta-analysis of the interplay between 3D chromatin organization and gene expression programs under basal and stress conditions

Epigenetics & Chromatin

Aug 31, 2018

Idan NurickRan Elkon

PMID: 30157915

DOI: 10.1186/s13072-018-0220-2

Abstract

Our appreciation of the critical role of the genome's 3D organization in gene regulation is steadily increasing. Recent 3C-based deep sequencing techniques elucidated a hierarchy of structures that underlie the spatial organization of the genome in the nucleus. At the top of this hierar...read more

Mentioned in this Paper

Meta-Analysis (Publications)
Nucleic Acid Sequence Based Analysis
Meta Analysis (Statistical Procedure)
Invariant Natural Killer T-Cells
Genome
Three-dimensional
Regulation of Biological Process
Transcription, Genetic
Tissue-Specific Gene Expression
Promoter
4
33

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The 3-D organization of chromatin is an important factor in the regulation of gene expression. Find the latest research on nuclear architecture here.

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Molecular Cell

The hierarchy of the 3D genome

Molecular CellMarch 12, 2013
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Alterations in Three-Dimensional Organization of the Cancer Genome and Epigenome

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Paper Details
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