Genomic Organization and Expression of Iron Metabolism Genes in the Emerging Pathogenic Mold Scedosporium apiospermum

Frontiers in Microbiology
Yohann Le GovicPatrick Vandeputte

Abstract

The ubiquitous mold Scedosporium apiospermum is increasingly recognized as an emerging pathogen, especially among patients with underlying disorders such as immunodeficiency or cystic fibrosis (CF). Indeed, it ranks the second among the filamentous fungi colonizing the respiratory tract of CF patients. However, our knowledge about virulence factors of this fungus is still limited. The role of iron-uptake systems may be critical for establishment of Scedosporium infections, notably in the iron-rich environment of the CF lung. Two main strategies are employed by fungi to efficiently acquire iron from their host or from their ecological niche: siderophore production and reductive iron assimilation (RIA) systems. The aim of this study was to assess the existence of orthologous genes involved in iron metabolism in the recently sequenced genome of S. apiospermum. At first, a tBLASTn analysis using A. fumigatus iron-related proteins as query revealed orthologs of almost all relevant loci in the S. apiospermum genome. Whereas the genes putatively involved in RIA were randomly distributed, siderophore biosynthesis and transport genes were organized in two clusters, each containing a non-ribosomal peptide synthetase (NRPS) whose ortholog...Continue Reading

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Citations

Dec 24, 2019·Expert Review of Respiratory Medicine·Jean-Philippe BoucharaGilles Nevez
Sep 26, 2019·Frontiers in Microbiology·Yohann Le GovicPatrick Vandeputte
Aug 6, 2019·Trends in Microbiology·Jean-Philippe Bouchara, Nicolas Papon

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Methods Mentioned

BETA
scraping
PCR
electrophoresis

Software Mentioned

BLASTp
tBLASTn
MEME Suite

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