Genomic organization of mouse Dishevelled genes

Gene
Y YangM Tsang

Abstract

We report the isolation and characterization of two new genomic loci corresponding to the mouse Dishevelled (Dvl) genes Dvl2 and Dvl3. The Dvl genes are homologs of the Drosophila dsh segment polarity gene, and are involved in the Wnt/wingless signal transduction pathway. Dvl2 and Dvl3 genomic clones were isolated from a mouse 129 strain gamma FIXII genomic library and have identical exon/intron organization to Dvl1. All three Dishevelled genes span 15 exons and 14 introns and have a number of conserved splice junction sites.

References

Oct 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·D R BeierD J Sussman
Jun 26, 1992·Cell·R Nusse, H E Varmus
Jan 22, 1982·Nucleic Acids Research·S M Mount
May 1, 1995·Genes & Development·S YanagawaR Nusse
Jan 6, 1994·Nature·E SiegfriedN Perrimon
Jan 1, 1994·Genes & Development·S TakadaA P McMahon
Jul 1, 1996·In Vitro Cellular & Developmental Biology. Animal·S A SteitzD J Sussman
Sep 1, 1995·Genome Research·N Lijam, D J Sussman

❮ Previous
Next ❯

Citations

Jul 11, 2002·Mutation Research·Masao S SasakiTaisei Nomura
May 28, 2004·The Journal of Comparative Neurology·A Abu-KhalilDaniel H Geschwind
Dec 22, 2012·Growth Factors·Kenyi Saito-DiazEthan Lee
Oct 29, 2004·The Journal of Biological Chemistry·Yoshimi EndoJeffrey S Rubin
Dec 17, 2009·Cellular Signalling·Chan Gao, Ye-Guang Chen

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.