Genomic Patterns of Geographic Differentiation in Drosophila simulans

Genetics
Alisa SedghifarDavid J Begun

Abstract

Geographic patterns of genetic differentiation have long been used to understand population history and to learn about the biological mechanisms of adaptation. Here we present an examination of genomic patterns of differentiation between northern and southern populations of Australian and North American Drosophila simulans, with an emphasis on characterizing signals of parallel differentiation. We report on the genomic scale of differentiation and functional enrichment of outlier SNPs. While, overall, signals of shared differentiation are modest, we find the strongest support for parallel differentiation in genomic regions that are associated with regulation. Comparisons to Drosophila melanogaster yield potential candidate genes involved in local adaptation in both species, providing insight into common selective pressures and responses. In contrast to D. melanogaster, in D. simulans we observe patterns of variation that are inconsistent with a model of temperate adaptation out of a tropical ancestral range, highlighting potential differences in demographic and colonization histories of this cosmopolitan species pair.

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Citations

Dec 12, 2017·Genome Biology and Evolution·Sarah A SignorSergey Nuzhdin
Sep 25, 2018·PLoS Genetics·Megan Phifer-RixeyMichael W Nachman
Nov 30, 2018·Molecular Ecology·Jeffrey R AdrionMatthew W Hahn
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May 14, 2020·Genetics·Matthew M Osmond, Graham Coop
May 28, 2019·Proceedings of the National Academy of Sciences of the United States of America·Lin KangPawel Michalak
May 27, 2017·G3 : Genes - Genomes - Genetics·Neda BarghiChristian Schlötterer
May 14, 2020·Molecular Biology and Evolution·Ana Marija JakšićChristian Schlötterer
Oct 3, 2017·PLoS Genetics·Li Zhao, David J Begun
Oct 31, 2020·BMC Biology·Anna Maria LangmüllerChristian Schlötterer
Apr 30, 2021·PLoS Genetics·Kathleen G FerrisMichael W Nachman

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