Genomic platforms for cancer research: potential diagnostic and prognostic applications in clinical oncology.

Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico
Pedro Jares, Elías Campo

Abstract

The completion of the Human Genome Project and the achievement of similar goals in other organisms have generated a huge amount of free available information with high potential in biomedical sciences. However, the identification of the DNA sequence was only a starting point for genomic research. This research has been facilitated by the development of new powerful genomic tools that allow the use of the wide amount of genomic information generated to address new biological and biomedical questions. One of these widely accepted and accessible technologies is DNA microarrays. Although the most popular use of DNA microarrays is gene expression profiling, due to the continuous advances in microarray technologies, scientists have also successfully used them for multiple applications, including genotyping, re-sequencing, DNA copy number analysis and DNA methylation. In short, DNA microarrays are changing the way cancer research scientists are addressing different biological questions and will allow the translation of genome research to clinical practice.

References

Dec 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·F Antequera, A Bird
Sep 3, 1996·Proceedings of the National Academy of Sciences of the United States of America·J G HermanS B Baylin
Dec 31, 1997·Genes, Chromosomes & Cancer·S Solinas-ToldoP Lichter
Jul 24, 1998·Trends in Biotechnology·M SchenaR W Davis
Jan 23, 1999·Nature Genetics·E SouthernM Shchepinov
Jan 23, 1999·Nature Genetics·D J DugganJ M Trent
Jan 23, 1999·Nature Genetics·V G CheungG Childs
Jan 23, 1999·Nature Genetics·R J LipshutzD J Lockhart
Jun 23, 1999·Proceedings of the National Academy of Sciences of the United States of America·S A AhrendtD Sidransky
Aug 26, 1999·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·S GranjeaudB R Jordan
Sep 2, 1999·Nature Genetics·J R PollackP O Brown
Aug 30, 2000·Nature·C M PerouD Botstein
Feb 22, 2001·Science·J C VenterX Zhu
Mar 10, 2001·BioTechniques·V N KristensenA L Børresen-Dale
Mar 10, 2001·Nature·E S LanderUNKNOWN International Human Genome Sequencing Consortium
Mar 10, 2001·Nature Genetics·L Kruglyak, D A Nickerson
Nov 10, 2001·Annual Review of Genomics and Human Genetics·K U Mir, E M Southern
Dec 4, 2001·Nature Genetics·Scott A ArmstrongStanley J Korsmeyer
Feb 2, 2002·Nature·Laura J van 't VeerStephen H Friend
Feb 28, 2002·Nucleic Acids Research·Péter AdorjánAlexander Olek
Mar 28, 2002·Nucleic Acids Research·Ramesh RamakrishnanAbhijit Mazumder
Mar 30, 2002·Nature Biotechnology·Wei-Wen CaiAllan Bradley
May 4, 2002·Science·Philipp KapranovThomas R Gingeras
Jun 18, 2002·Trends in Molecular Medicine·Robert S NegmSudhir Srivastava
Jun 21, 2002·The New England Journal of Medicine·Andreas RosenwaldUNKNOWN Lymphoma/Leukemia Molecular Profiling Project
Aug 16, 2002·Journal of Human Genetics·Izuho HatadaKenichi Matsubara
Sep 28, 2002·Human Molecular Genetics·Christoph Plass
Nov 28, 2002·Nature Genetics·Andrew J HollowayDavid D L Bowtell
Dec 5, 2002·Neurochemical Research·Timothy J SenderaAbhijit Mazumder
Dec 20, 2002·The New England Journal of Medicine·Marc J van de VijverRené Bernards
Feb 6, 2003·Drug Discovery Today·J Carl Barrett, Ernest S Kawasaki

❮ Previous
Next ❯

Citations

Jun 23, 2010·Human Molecular Genetics·Marie-Thérèse BessonJean-Charles Liévens

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.