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Genomic profiling identifies association of IDH1/IDH2 mutation with longer relapse free and metastasis free survival in high-grade chondrosarcoma

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research

Oct 15, 2019

Guo ZhuMeera R Hameed

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Abstract

Chondrosarcomas are the second most common primary malignant bone tumors. While histologic grade is the most important factor predicting the clinical outcome of chondrosarcoma, it is subject to interobserver variability. IDH1 and IDH2 hotspot mutations were recently found to be frequent...read more

Mentioned in this Paper

Malignant Neoplasms
Chondrosarcoma
Disease Susceptibility
Gene Amplification
Gene Deletion
Genes
Protein p53
Telomere
Promoter
Disease Progression
9
5
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Genomic profiling identifies association of IDH1/IDH2 mutation with longer relapse free and metastasis free survival in high-grade chondrosarcoma

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research

Oct 15, 2019

Guo ZhuMeera R Hameed

PMID: 31615936

DOI: 10.1158/1078-0432.ccr-18-4212

Abstract

Chondrosarcomas are the second most common primary malignant bone tumors. While histologic grade is the most important factor predicting the clinical outcome of chondrosarcoma, it is subject to interobserver variability. IDH1 and IDH2 hotspot mutations were recently found to be frequent...read more

Mentioned in this Paper

Malignant Neoplasms
Chondrosarcoma
Disease Susceptibility
Gene Amplification
Gene Deletion
9
5

Similar Papers Found In These Feeds

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