Genomic profiling identifies TITF1 as a lineage-specific oncogene amplified in lung cancer.

Oncogene
K A KweiJ R Pollack

Abstract

Lung cancer is a leading cause of cancer death, where the amplification of oncogenes contributes to tumorigenesis. Genomic profiling of 128 lung cancer cell lines and tumors revealed frequent focal DNA amplification at cytoband 14q13.3, a locus not amplified in other tumor types. The smallest region of recurrent amplification spanned the homeobox transcription factor TITF1 (thyroid transcription factor 1; also called NKX2-1), previously linked to normal lung development and function. When amplified, TITF1 exhibited increased expression at both the RNA and protein levels. Small interfering RNA (siRNA)-mediated knockdown of TITF1 in lung cancer cell lines with amplification led to reduced cell proliferation, manifested by both decreased cell-cycle progression and increased apoptosis. Our findings indicate that TITF1 amplification and overexpression contribute to lung cancer cell proliferation rates and survival and implicate TITF1 as a lineage-specific oncogene in lung cancer.

References

Sep 2, 1999·Nature Genetics·J R PollackP O Brown
Mar 30, 2002·Molecular Endocrinology·Stefania MiccadeiDonato Civitareale
May 23, 2002·The American Journal of Surgical Pathology·Yasushi YatabeTakashi Takahashi
Jun 5, 2002·Genome Research·W James KentDavid Haussler
Sep 26, 2002·Proceedings of the National Academy of Sciences of the United States of America·Jonathan R PollackPatrick O Brown
Jan 9, 2004·Proceedings of the National Academy of Sciences of the United States of America·Jacques LapointeJonathan R Pollack
Jul 23, 2005·Neoplasia : an International Journal for Oncology Research·Murali D BashyamJonathan R Pollack
Feb 21, 2006·Nature Methods·Amanda BirminghamAnastasia Khvorova
Jul 25, 2006·Nature Reviews. Cancer·Levi A Garraway, William R Sellers
Jan 24, 2007·CA: a Cancer Journal for Clinicians·Ahmedin JemalMichael J Thun
Apr 6, 2007·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Mitsuo SatoJohn D Minna
Apr 10, 2007·Nature Genetics·Frederik HolstRonald Simon
May 22, 2007·Biostatistics·Robert Tibshirani, Pei Wang
Jul 10, 2007·Cancer Research·Hisaaki TanakaTakashi Takahashi
Sep 19, 2007·Cancer Research·Jacques LapointeJonathan R Pollack
Oct 11, 2007·Proceedings of the National Academy of Sciences of the United States of America·Jude KendallDavid Mu
Nov 6, 2007·Nature·Barbara A WeirMatthew Meyerson
Jan 22, 2013·CA: a Cancer Journal for Clinicians·Rebecca SiegelAhmedin Jemal

❮ Previous
Next ❯

Citations

Sep 21, 2010·Der Pathologe·I Petersen
Jan 29, 2010·Cancer Metastasis Reviews·Raj ChariWan L Lam
Apr 25, 2012·Frontiers of Medicine·Ji Qi, David Mu
Sep 18, 2010·Pathology Oncology Research : POR·Andras KhoorSanto V Nicosia
Nov 19, 2011·Leukemia·I HommingaJ P P Meijerink
Apr 5, 2011·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Theresia WilbertzSven Perner
Apr 8, 2011·Nature·Monte M WinslowTyler Jacks
Apr 18, 2013·Nature Communications·Il-Jin KimAllan Balmain
Oct 24, 2009·Nature Reviews. Cancer·Adrian P Bracken, Kristian Helin
Mar 13, 2009·Proceedings of the National Academy of Sciences of the United States of America·David S HsuAnil Potti
Nov 1, 2012·Proceedings of the National Academy of Sciences of the United States of America·Keyan SalariJonathan R Pollack
Jul 5, 2012·The Journal of Biological Chemistry·E Aaron RunkleDavid Mu
Aug 4, 2010·Journal of the National Cancer Institute·Adi F GazdarJohn D Minna
Dec 14, 2011·The Cancer Journal·Jill E LarsenJohn D Minna
Nov 2, 2011·Respirology : Official Journal of the Asian Pacific Society of Respirology·Humam KadaraIgnacio I Wistuba
Jul 26, 2011·American Journal of Physiology. Lung Cellular and Molecular Physiology·Aparajita DasVijay Boggaram
Jan 25, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Ximing TangIgnacio I Wistuba
Dec 15, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Thomas HarrisJoseph Locker
Dec 18, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Joel W Neal, Alice T Shaw
Jun 7, 2011·American Journal of Respiratory and Critical Care Medicine·Jeffrey A WhitsettYutaka Maeda
May 20, 2009·The Journal of Clinical Investigation·Martin L SosRoman K Thomas
Nov 13, 2012·The Journal of Clinical Investigation·Yutaka MaedaJeffrey A Whitsett
Jun 2, 2009·The European Respiratory Journal·E Brambilla, A Gazdar
Oct 31, 2009·BMC Medical Genomics·Xiaosheng Wang, Osamu Gotoh
Aug 29, 2012·Biochemistry Research International·Jackie L JohnsonSrikumar P Chellappan

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.

Cancer Genomics (Keystone)

Cancer genomics approaches employ high-throughput technologies to identify the complete catalog of somatic alterations that characterize the genome, transcriptome and epigenome of cohorts of tumor samples. Discover the latest research using such technologies in this feed.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis