Genomic Profiling of Circulating Tumor DNA From Cerebrospinal Fluid to Guide Clinical Decision Making for Patients With Primary and Metastatic Brain Tumors

Frontiers in Neurology
Lori A RamkissoonShakti H Ramkissoon

Abstract

Despite advances in systemic therapies for solid tumors, the development of brain metastases remains a significant contributor to overall cancer mortality and requires improved methods for diagnosing and treating these lesions. Similarly, the prognosis for malignant primary brain tumors remains poor with little improvement in overall survival over the last several decades. In both primary and metastatic central nervous system (CNS) tumors, the challenge from a clinical perspective centers on detecting CNS dissemination early and understanding how CNS lesions differ from the primary tumor, in order to determine potential treatment strategies. Acquiring tissue from CNS tumors has historically been accomplished through invasive neurosurgical procedures, which restricts the number of patients to those who can safely undergo a surgical procedure, and for which such interventions will add meaningful value to the care of the patient. In this review we discuss the potential of analyzing cell free DNA shed from tumor cells that is contained within the cerebrospinal fluid (CSF) as a sensitive and minimally invasive method to detect and characterize primary and metastatic tumors in the CNS.

References

Oct 11, 2005·Cancer Treatment and Research·Craig P Nolan, Lauren E Abrey
May 5, 2010·Neurology·J L ClarkeL M Deangelis
Mar 15, 2011·Oncotarget·Jian HeNickolas Papadopoulos
May 3, 2012·Nature Reviews. Urology·Matthew J Murray, Nicholas Coleman
Jun 8, 2012·Science Translational Medicine·Jacob O KitzmanJay Shendure
Jul 6, 2012·Nature·H Christina FanStephen R Quake
Jan 23, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Luis A Diaz, Alberto Bardelli
Jul 22, 2015·Proceedings of the National Academy of Sciences of the United States of America·Yuxuan WangChetan Bettegowda
Dec 25, 2015·Leukemia & Lymphoma·Joo Hyun KimChaehwa Park
May 11, 2016·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Elena I PentsovaMichael F Berger
Oct 21, 2016·Neurosurgery·Patrick A TullyAndrew P Morokoff
Feb 9, 2017·Annals of Oncology : Official Journal of the European Society for Medical Oncology·R CostaF J Giles
Jun 18, 2017·Cancer Discovery·Christian GrommesIngo K Mellinghoff
Dec 9, 2017·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·P D Delgado-LópezE M Corrales-García
Jan 26, 2018·Acta Neuropathologica·Jean-François Ghersi-EgeaBritta Engelhardt
Feb 11, 2018·World Neurosurgery·Yi-Ren ChenStephen Skirboll
Apr 5, 2018·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Francisco Martínez-RicarteJoan Seoane
May 20, 2018·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Oliver A ZillAmirAli Talasaz
Aug 17, 2018·Acta Neuropathologica Communications·Stefanie StallardCarl Koschmann
Jan 25, 2019·Nature·Alexandra M MillerIngo K Mellinghoff
Jan 7, 2020·Theranostics·Louisa von BaumgartenChristoph Benedikt Westphalen

❮ Previous
Next ❯

Citations

Jun 10, 2021·The Oncologist·Richard S P HuangShakti H Ramkissoon

❮ Previous
Next ❯

Methods Mentioned

BETA
surgical resection
biopsy
flow cytometry
PCR
Assay
biopsies

Related Concepts

Related Feeds

CSF & Lymphatic System

This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.

© 2021 Meta ULC. All rights reserved