PMID: 8810007May 1, 1996Paper

Genomic, protein homogeneity and antigenic variability of Mycoplasma agalactiae

Veterinary Microbiology
M SolsonaFrançois Poumarat

Abstract

Eleven strains of Mycoplasma agalactiae differing in pathogenicity, animal species origin and geographic localisation, showed similar chromosome restriction profiles with four endonucleases. However the international reference strain PG2 showed a unique profile. The protein and antigenic variabilities of 31 strains of M. agalactiae were investigated using sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE) and immunoblotting performed with naturally infected animal sera and purified antibodies against the 29 kDa protein. Protein profiles were similar but antigenic profiles could be separated into two main groups according to geographic origin: (i) strains isolated in south-west France and (ii) strains from north-east France. Some differences also occurred from strain to strain within each group. The antigenic profile variability found in immunoblotting, originated in two different phenomena: (i) some epitopes were expressed only in strains of one profile type and (ii) some other epitopes were common to all strains but located on several proteins which differed in number and molecular mass from one strain to another. The presence of epitopes which undergo phase variation in the same lineage of clones from a sing...Continue Reading

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Citations

Oct 17, 1998·Comparative Immunology, Microbiology and Infectious Diseases·B A Salih, R F Rosenbusch
Feb 13, 2001·Veterinary Microbiology·F Dufour-GesbertM Kobisch
Jun 22, 2010·Journal of Bacteriology·Stefan CzurdaRohini Chopra-Dewasthaly
Dec 12, 2012·Journal of Clinical Microbiology·Jaime Ariza-MiguelMarta Hernández
Sep 8, 2005·Journal of Clinical Microbiology·Tim StakenborgMario Vaneechoutte
Feb 6, 2008·Molecular Microbiology·Rohini Chopra-DewasthalyWolfgang Jechlinger
Feb 18, 2005·International Journal of Medical Microbiology : IJMM·Rohini Chopra-DewasthalyChristine Citti
Mar 5, 2011·Journal of Medical Microbiology·L McAuliffeR J Ellis
Aug 7, 2014·Veterinary Medicine International·Amit KumarKuldeep Dhama
Jul 20, 2012·FEMS Immunology and Medical Microbiology·Rohini Chopra-DewasthalyJoachim Spergser
Oct 11, 2005·FEMS Microbiology Letters·Rohini Chopra-DewasthalyChristine Citti

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