Genomic regulation of natural variation in cortical and noncortical brain volume

BMC Neuroscience
Jackson Beatty, Rick E Laughlin

Abstract

The relative growth of the neocortex parallels the emergence of complex cognitive functions across species. To determine the regions of the mammalian genome responsible for natural variations in cortical volume, we conducted a complex trait analysis using 34 strains of recombinant inbred (Rl) strains of mice (BXD), as well as their two parental strains (C57BL/6J and DBA/2J). We measured both neocortical volume and total brain volume in 155 coronally sectioned mouse brains that were Nissl stained and embedded in celloidin. After correction for shrinkage, the measured cortical and noncortical brain volumes were entered into a multiple regression analysis, which removed the effects of body size and age from the measurements. Marker regression and interval mapping were computed using WebQTL. An ANOVA revealed that more than half of the variance of these regressed phenotypes is genetically determined. We then identified the regions of the genome regulating this heritability. We located genomic regions in which a linkage disequilibrium was present using WebQTL as both a mapping engine and genomic database. For neocortex, we found a genome-wide significant quantitative trait locus (QTL) on chromosome 11 (marker D11Mit19), as well as a...Continue Reading

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Citations

Jun 3, 2010·CBE Life Sciences Education·William GrishamJackson Beatty
Apr 1, 2010·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Karen B LarsenMorten Møller
Dec 15, 2015·Nature Communications·Liesbeth ZwartsPatrick Callaerts
Dec 24, 2017·The Journal of Biological Chemistry·Baoshan HuangJie-Guang Chen
Sep 15, 2007·Brain : a Journal of Neurology·Lara MenziesEd Bullmore
Aug 14, 2009·Expert Review of Neurotherapeutics·Samuel R Chamberlain, Lara Menzies

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Software Mentioned

NIH ImageJ
Celera
MathType
ImageJ
WebQTL

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