Genomic reorganization in the concolor gibbon (Hylobates concolor) revealed by chromosome painting

Genomics
U KoehlerR Stanyon

Abstract

We employed fluorescence in situ hybridization (FISH) of specific DNA libraries of all human chromosomes to establish homologies between the human karyotype and the karyotype of Hylobates concolor (2n = 52). Numerous intra- and interchromosomal rearrangements have led to a massive reorganization in the karyotype of H. concolor. There have been a minimum of 31 translocations. The 25 H. concolor autosomes are composed of 63-67 recognizable segments that show DNA homology to regions of the 22 human autosomes. Only 1 autosome, homologous to human chromosome 21, has not been involved in translocations. We compared the gene mapping data for H. concolor with our in situ hybridization and found that in most cases these data are confirmed by our results. H. concolor presents a case in a primate closely related to humans, in which chromosome morphology and synteny are highly disturbed in a manner similar to that encountered in rodents.

Citations

Aug 31, 2001·ILAR Journal·Malcolm A. Ferguson-SmithPatricia C.M. O'Brien
Aug 31, 2001·ILAR Journal·Johannes Wienberg, Roscoe Stanyon
Aug 16, 2012·Genome Research·Oronzo CapozziNicoletta Archidiacono
Dec 23, 2006·Genome Research·Roberta RobertoEvan E Eichler
Nov 17, 2004·Cytogenetic and Genome Research·M A Ferguson-SmithP C M O'Brien
Jan 2, 2007·PLoS Genetics·Lucia CarbonePieter J de Jong
Jun 16, 2004·Proceedings of the National Academy of Sciences of the United States of America·Terje RaudseppBhanu P Chowdhary
Jan 5, 2000·Proceedings of the National Academy of Sciences of the United States of America·S MüllerJ Wienberg
Nov 29, 2014·Genome Génome / Conseil National De Recherches Canada·Chuanliang DengZanmin Hu
Jun 20, 2018·Genome Research·Nathan H LazarLucia Carbone
Sep 15, 2018·Current Protocols in Human Genetics·Chengsheng ZhangCharles Lee
Oct 9, 1999·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·D Haig
Apr 25, 2007·American Journal of Primatology·Keri MondaDavid S Woodruff
Feb 23, 2008·Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology·Vladimir A TrifonovFengtang Yang
Feb 23, 2008·Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology·Hildegard Kehrer-Sawatzki, David N Cooper
Jan 1, 1996·Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology·S MüllerN Archidiacono
Aug 6, 2008·Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology·Sibyle MoulinFlorence Anne Richard
Oct 16, 1999·Science·S J O'BrienJ A Marshall Graves
Jun 1, 1997·Mammalian Genome : Official Journal of the International Mammalian Genome Society·R ToderJ A Marshall-Graves
Jun 20, 2012·Cytogenetic and Genome Research·R StanyonN Archidiacono
Jul 26, 1996·Science·E SchröckT Ried

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.