Genomic structure and chromosomal localization of GML (GPI-anchored molecule-like protein), a gene induced by p53

Genomics
Y KimuraT Tokino

Abstract

Among its known functions, tumor suppressor gene p53 serves as a transcriptional regulator and mediates various signals through activation of downstream genes. We recently identified a novel gene, GML (glycosylphosphatidylinositol (GPI)-anchored molecule-like protein), whose expression is specifically induced by wildtype p53. To characterize the GML gene further, we determined 35.8 kb of DNA sequence that included a consensus binding sequence for p53 and the entire GML gene. The GML gene consists of four exons; and the p53-binding sequence is present in the 5'-flanking region. In genomic organization this gene resembles genes encoding murine Ly-6 glycoproteins, a human homologue of the Ly-6 family called RIG-E, and CD59; products of these genes, known as GPI-anchored proteins, are variously involved in signal transduction, cell-cell adhesion, and cell-matrix attachment. FISH analysis revealed that the GML gene is located on human chromosome 8q24.3. Genes encoding at least two other GPI-anchored molecules, E48 and RIG-E, are also located in this region.

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Citations

Sep 16, 1998·Proceedings of the National Academy of Sciences of the United States of America·T MashimoK Watabe
Jan 15, 2004·Cancer Science·Yusuke Nakamura
Oct 19, 2012·The FEBS Journal·Maiko KurosawaYoshikazu Kurosawa
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