PMID: 9434942Jan 22, 1998Paper

Genomic structure and chromosomal localization of the mouse Ogg1 gene that is involved in the repair of 8-hydroxyguanine in DNA damage

Mammalian Genome : Official Journal of the International Mammalian Genome Society
M TaniJ Yokota

Abstract

8-Hydroxyguanine (7,8-dihydro-8-oxoguanine: oh8Gua) is a damaged form of guanine induced by oxygen-free radicals and causes GC to TA transversions. Previously we isolated the hOGG1 gene, a human homolog of the yeast OGG1 gene, which encodes a DNA glycosylase and lyase to excise oh8Gua in DNA. In this study, we isolated a mouse homolog (Ogg1) of the OGG1 gene, characterized oh8Gua-specific DNA glycosylase/AP lyase activities of its product, and determined chromosomal localization and exon-intron organization of this gene. A predicted protein possessed five domains homologous to human and yeast OGG1 proteins. Helix-hairpin-helix and C2H2 zinc finger-like DNA-binding motifs found in human and yeast OGG1 proteins were also retained in mouse Ogg1 protein. The properties of a GST fusion protein were identical to human and yeast OGG1 proteins in glycosylase/lyase activities, their substrate specificities, and suppressive activities against the spontaneous mutagenesis of an Escherichia coli mutM mutY double mutant. The mouse Ogg1 gene was mapped to Chromosome (Chr) 6, and consisted of 7 exons approximately 6 kb long. Two DNA-binding motifs were encoded in exons 4 through 5. These data will facilitate the investigation of the OGG1 gene ...Continue Reading

References

Aug 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·M L MichaelsJ H Miller
Jan 1, 1991·Mammalian Genome : Official Journal of the International Mammalian Genome Society·K F Manly, R W Elliott
Jun 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·J TchouS Nishimura
Sep 1, 1990·Carcinogenesis·R A Floyd
Jul 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·T R O'Connor, J Laval
Nov 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·K G AuP Modrich
Apr 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·J R Totter
Jun 6, 1995·Proceedings of the National Academy of Sciences of the United States of America·B N AmesW C Willett
Dec 1, 1994·Mammalian Genome : Official Journal of the International Mammalian Genome Society·H ShibataM Katsuki
Jul 1, 1993·Trends in Genetics : TIG·A P Grollman, M Moriya
Jul 8, 1997·Proceedings of the National Academy of Sciences of the United States of America·T A RosenquistA P Grollman

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Citations

Apr 12, 2002·International Journal of Cancer. Journal International Du Cancer·Tokuo SukataShoji Fukushima
Apr 11, 2001·Mutation Research·I E Dreosti
Jun 28, 2002·Free Radical Biology & Medicine·Susan S Wallace
Oct 6, 2000·Mutation Research·A DhénautJ P Radicella
Aug 17, 2011·International Journal of Environmental Research and Public Health·Takeshi Hirano
Aug 2, 2001·Biochemical and Biophysical Research Communications·J E KimM H Chung
Jul 13, 2000·Proceedings of the National Academy of Sciences of the United States of America·F Le PageS Boiteux
Nov 11, 1999·Proceedings of the National Academy of Sciences of the United States of America·A KlunglandD E Barnes
May 17, 2011·Biochimica Et Biophysica Acta·Chi-Hui TangLimin Liu
Nov 2, 2016·The Journal of Clinical Investigation·Michel J MassaadRaif S Geha
Jul 23, 2003·Environmental and Molecular Mutagenesis·Jeffrey K WickliffeRobert J Baker
May 10, 2005·Environmental and Molecular Mutagenesis·Su-Ryang KimTakehiko Nohmi
Apr 15, 2000·Free Radical Research·M S CookeJ Lunec
Aug 24, 2001·American Journal of Physiology. Gastrointestinal and Liver Physiology·M JaiswalG J Gores
May 22, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·David B WinterPatricia J Gearhart

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