Genomic structure, evolution, and expression of human FLII, a gelsolin and leucine-rich-repeat family member: overlap with LLGL

Genomics
H D CampbellJ R Lupski

Abstract

The Drosophila melanogaster flightless-I gene is involved in cellularization processes in early embryogenesis and in the structural organization of indirect flight muscle. The encoded protein contains a gelsolin-like actin binding domain and an N-terminal leucine-rich repeat protein-protein interaction domain. The homologous human FLII gene encodes a 1269-residue protein with 58% amino acid sequence identity and is deleted in Smith-Magenis syndrome. We have cloned the FLII gene and determined its nucleotide sequence (14.1 kb). FLII has 29 introns, compared with 13 in Caenorhabditis elegans and 3 in D. melanogaster. The positions of several introns are conserved in FLII-related genes and in the domains and subdomains of the gelsolin-like regions giving indications of gelsolin gene family evolution. In keeping with its function in indirect flight muscle in Drosophila, the human FLII gene was most highly expressed in muscle. The FLII gene lies adjacent to LLGL, the human homologue of the D. melanogaster tumor suppressor gene lethal(2) giant larvae. The 3' end of the FLII transcript overlaps the 3' end of the LLGL transcript, and the corresponding mouse genes Fliih and Llglh also overlap. The overlap region contains poly(A) signals...Continue Reading

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Citations

Jul 17, 2008·Comparative and Functional Genomics·Fabienne S GiraudeauIan C Gray
Mar 19, 2009·The Journal of Biological Chemistry·Jun XuZhou Songyang
Apr 25, 2002·Molecular and Cellular Biology·Hugh D CampbellKlaus I Matthaei
Nov 8, 2011·Genetics and Molecular Research : GMR·B F GambaD Morreti-Ferreira
May 9, 1998·Proceedings of the National Academy of Sciences of the United States of America·R MaleszkaG L Miklos
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Mar 25, 2011·The Journal of Investigative Dermatology·Zlatko KopeckiAllison J Cowin
Mar 17, 2005·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Stuart K ArcherHugh D Campbell
Sep 6, 2005·Traffic·Jan GettemansVeerle De Corte
Oct 25, 2013·Cytoskeleton·Umesh GhoshdastiderRobert C Robinson
Jul 26, 2011·Genesis : the Journal of Genetics and Development·Nicole ThomsenRuth M Arkell
Dec 3, 2014·Fish & Shellfish Immunology·Shuang ZhangJian-Guo He
Jul 28, 2016·Molecular and Cellular Probes·Mei LiuHong Chen
Mar 14, 2002·The Journal of Biological Chemistry·Abolfazl AsadiAnders Jacobsson
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Dec 18, 2020·Frontiers in Cell and Developmental Biology·Xanthe L Strudwick, Allison J Cowin
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