PMID: 9550322Apr 29, 1998Paper

Genomic structure of PIR-B, the inhibitory member of the paired immunoglobulin-like receptor genes in mice

Tissue Antigens
T L AlleyH Kubagawa

Abstract

The genes encoding the murine paired immunoglobulin-like receptors PIR-A and PIR-B are members of a novel gene family which encode cell-surface receptors bearing immunoreceptor tyrosine-based inhibitory motifs (ITIMs) and their non-inhibitory/activatory counterparts. PIR-A and PIR-B have highly homologous extracellular domains but distinct transmembrane and cytoplasmic regions. A charged arginine in the transmembrane region of PIR-A suggests its potential association with other transmembrane proteins to form a signal transducing unit. PIR-B, in contrast, has an uncharged transmembrane region and several ITIMs in its cytoplasmic tail. These characteristics suggest that PIR-A and PIR-B which are coordinately expressed by B cells and myeloid cells, serve counter-regulatory roles in humoral and inflammatory responses. In the present study we have determined the genomic structure of the single copy PIR-B gene. The gene consists of 15 exons and spans approximately 8 kilobases. The first exon contains the 5' untranslated region, the ATG translation start site, and approximately half of the leader peptide sequence. The remainder of the leader peptide sequence is encoded by exon 2. Exons 3-8 encode the six extracellular immunoglobulin-l...Continue Reading

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Citations

Feb 3, 2005·European Journal of Immunology·Randall S DavisMax D Cooper
Jan 12, 1999·The Journal of Clinical Investigation·P J Newman
Jan 20, 1999·The Journal of Experimental Medicine·H KubagawaM D Cooper
Jun 9, 1999·Proceedings of the National Academy of Sciences of the United States of America·C C ChenM D Cooper
Dec 21, 2002·Immunological Reviews·Randall S DavisMax D Cooper
Jan 5, 2007·Annual Review of Immunology·Randall S Davis
Nov 15, 2000·Proceedings of the National Academy of Sciences of the United States of America·G DennisM D Cooper
Dec 28, 1999·Proceedings of the National Academy of Sciences of the United States of America·L H HoM D Cooper
Feb 17, 2019·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yanbin FuYaofeng Zhao
May 11, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kojo AritaToshiyuki Takai

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