Genomic structures and chromosomal location of p91, a novel murine regulatory receptor family

Journal of Biochemistry
Y YamashitaT Takai

Abstract

Recently, we found a novel murine cell-surface glycoprotein, designated as p91, expressed mainly in myeloid cells such as macrophages and mast cells. The molecule has six immunoglobulin-like extracellular domains, a transmembrane segment, and a cytoplasmic tail containing four immunoreceptor tyrosine-based inhibition motif (ITIM) or ITIM-like sequences, resembling the structural features of human killer-cell inhibitory receptors (KIR). Here we show that p91 comprises a polymorphic gene family, harboring one potent inhibitory-type p91 and at least two other p91 genes. Tyrosine-phosphorylated, but not nonphosphorylated, synthetic peptides matching the third ITIM and the fourth ITIM-like sequences, respectively, found in the cytoplasmic portion of p91A, the sole inhibitory-type p91, were associated with the tyrosine phosphatases, SHP-1 and SHP-2. In addition, the phosphotyrosyl peptide matching the third ITIM sequence also bound the inositol 5-phosphatase, SHIP. These results support the notion that p91A may function as an inhibitory cell-surface molecule against cell activation. The p91 genes were shown to be clustered in the proximal region of mouse chromosome 7, a syntenic position of human chromosome 19 where the genes for the...Continue Reading

Citations

Feb 16, 2000·Biochemical and Biophysical Research Communications·M XuZ J Zhao
Feb 13, 2001·Biochemical and Biophysical Research Communications·M J XuZ J Zhao
Aug 18, 2010·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Yingchun ZhouXuxia Yi
Jun 19, 2001·Current Opinion in Immunology·L L Lanier
Jan 13, 2000·Current Opinion in Immunology·A M Scharenberg
May 18, 2004·Nature Immunology·Akira NakamuraToshiyuki Takai
Mar 3, 2009·Proceedings of the National Academy of Sciences of the United States of America·Masanori InuiToshiyuki Takai
Jan 20, 1999·The Journal of Experimental Medicine·H KubagawaM D Cooper
Apr 11, 2007·The Journal of Experimental Medicine·Ai MasudaToshiyuki Takai
Oct 27, 2010·Journal of Biomedicine & Biotechnology·Toshiyuki TakaiShota Endo
Dec 22, 2012·American Journal of Respiratory Cell and Molecular Biology·Danielle Karo-AtarAriel Munitz
Oct 3, 2001·The Journal of Clinical Investigation·T UeharaH Kubagawa
May 18, 2006·Blood·Vinit G KarurDon M Wojchowski
Jun 9, 1999·Proceedings of the National Academy of Sciences of the United States of America·C C ChenM D Cooper
Dec 28, 1999·Proceedings of the National Academy of Sciences of the United States of America·L H HoM D Cooper
Apr 26, 2000·Proceedings of the National Academy of Sciences of the United States of America·M J WilsonJ Trowsdale
Nov 22, 2011·Neurochemical Research·Xiaofeng CaiJian Ye
Jul 22, 2009·Molecular and Cellular Neurosciences·Zixuan CaoFrank S Walsh
Jan 19, 2008·Scandinavian Journal of Immunology·D J GibbingsA D Befus
May 22, 2002·Nature Immunology·Azusa UjikeToshiyuki Takai
May 11, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kojo AritaToshiyuki Takai
Oct 25, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·K H LeeT Takai
Oct 17, 2019·Frontiers in Immunology·John C SchwartzJohn A Hammond
Sep 13, 2000·The Journal of Allergy and Clinical Immunology·V L Ott, J C Cambier
Jun 8, 2002·Biochemical and Biophysical Research Communications·Ming-jiang XuZhizhuang Joe Zhao

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