Genomic study and Medical Subject Headings enrichment analysis of early pregnancy rate and antral follicle numbers in Nelore heifers

Journal of Animal Science
G A Oliveira JúniorJ B S Ferraz

Abstract

Zebu animals () are known to take longer to reach puberty compared with taurine animals (), limiting the supply of animals for harvest or breeding and impacting profitability. Genomic information can be a helpful tool to better understand complex traits and improve genetic gains. In this study, we performed a genomewide association study (GWAS) to identify genetic variants associated with reproductive traits in Nelore beef cattle. Heifer pregnancy (HP) was recorded for 1,267 genotyped animals distributed in 12 contemporary groups (CG) with an average pregnancy rate of 0.35 (±0.01). Disregarding one of these CG, the number of antral follicles (NF) was also collected for 937 of these animals, with an average of 11.53 (±4.43). The animals were organized in CG: 12 and 11 for HP and NF, respectively. Genes in linkage disequilibrium (LD) with the associated variants can be considered in a functional enrichment analysis to identify biological mechanisms involved in fertility. Medical Subject Headings (MeSH) were detected using the MESHR package, allowing the extraction of broad meanings from the gene lists provided by the GWAS. The estimated heritability for HP was 0.28 ± 0.07 and for NF was 0.49 ± 0.09, with the genomic correlation b...Continue Reading

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Citations

Jul 28, 2018·Journal of Animal Science·Thaise P MeloRoberto Carvalheiro
Sep 22, 2018·Clinical Anatomy : Official Journal of the American Association of Clinical Anatomists & the British Association of Clinical Anatomists·Jonas KeilerAndreas Wree
Jan 1, 2020·Journal of Animal Science and Biotechnology·Gerson A Oliveira JúniorDorian J Garrick
Aug 16, 2019·Journal of Animal Breeding and Genetics = Zeitschrift Für Tierzüchtung Und Züchtungsbiologie·Thaise Pinto de MeloRoberto Carvalheiro
May 6, 2020·Animal Frontiers : the Review Magazine of Animal Agriculture·Ricardo Vieira VenturaLuiz F Brito
Oct 6, 2020·Journal of Animal Science and Biotechnology·Sarah E Moorey, Fernando H Biase
Sep 14, 2019·Animal Reproduction Science·Robert A CushmanAdam F Summers
Jul 3, 2021·Reproduction, Fertility, and Development·Jennifer L JuengelPeter Smith
Oct 9, 2021·Nature Ecology & Evolution·Hans RecknagelKathryn R Elmer

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