Genomic Surveillance for SARS-CoV-2 Variants Circulating in the United States, December 2020-May 2021.

MMWR. Morbidity and Mortality Weekly Report
Prabasaj PaulBenjamin J Silk

Abstract

SARS-CoV-2, the virus that causes COVID-19, is constantly mutating, leading to new variants (1). Variants have the potential to affect transmission, disease severity, diagnostics, therapeutics, and natural and vaccine-induced immunity. In November 2020, CDC established national surveillance for SARS-CoV-2 variants using genomic sequencing. As of May 6, 2021, sequences from 177,044 SARS-CoV-2-positive specimens collected during December 20, 2020-May 6, 2021, from 55 U.S. jurisdictions had been generated by or reported to CDC. These included 3,275 sequences for the 2-week period ending January 2, 2021, compared with 25,000 sequences for the 2-week period ending April 24, 2021 (0.1% and 3.1% of reported positive SARS-CoV-2 tests, respectively). Because sequences might be generated by multiple laboratories and sequence availability varies both geographically and over time, CDC developed statistical weighting and variance estimation methods to generate population-based estimates of the proportions of identified variants among SARS-CoV-2 infections circulating nationwide and in each of the 10 U.S. Department of Health and Human Services (HHS) geographic regions.* During the 2-week period ending April 24, 2021, the B.1.1.7 and P.1 var...Continue Reading

References

Jul 17, 2020·Nature Microbiology·Andrew RambautOliver G Pybus
Jan 22, 2021·MMWR. Morbidity and Mortality Weekly Report·Summer E GallowayVivien G Dugan
Mar 5, 2021·Science·Nicholas G DaviesW John Edmunds
May 15, 2021·MMWR. Morbidity and Mortality Weekly Report·Lindsey Martin WebbRachel Herlihy

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Citations

Jun 26, 2021·Thrombosis and Haemostasis·Grigoris T GerotziafasUNKNOWN Scientific Reviewer Committee
Aug 4, 2021·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Matthew BiggerstaffJay C Butler
Oct 27, 2021·Expert Review of Vaccines·Bhaswati Chatterjee, Suman S Thakur
Nov 3, 2021·Emerging Microbes & Infections·Kyle RosenkeHeinz Feldmann

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