Genomic variant in CAV1 increases susceptibility to coronary artery disease and myocardial infarction

Atherosclerosis
Shanshan ChenQing K Wang

Abstract

The CAV1 gene encodes caveolin-1 expressed in cell types relevant to atherosclerosis. Cav-1-null mice showed a protective effect on atherosclerosis under the ApoE(-/-) background. However, it is unknown whether CAV1 is linked to CAD and MI in humans. In this study we analyzed a tagSNP for CAV1 in intron 2, rs3807989, for potential association with CAD. We performed case-control association studies in three independent Chinese Han populations from GeneID, including 1249 CAD cases and 841 controls in Population I, 1260 cases and 833 controls in Population II and 790 cases and 1212 controls in Population III (a total of 3299 cases and 2886 controls). We identified significant association between rs3807989 and CAD in three independent populations and in the combined population (Padj = 2.18 × 10(-5), OR = 1.19 for minor allele A). We also detected significant association between rs3807989 and MI (Padj = 5.43 × 10(-5), OR = 1.23 for allele A). Allele A of SNP rs3807989 was also associated with a decreased level of LDL cholesterol. Although rs3807989 is a tagSNP for both CAV1 and nearby CAV2, allele A of SNP rs3807989 was associated with an increased expression level of CAV1 (both mRNA and protein), but not CAV2. The data in this stud...Continue Reading

References

Sep 12, 2002·Pharmacological Reviews·Babak RazaniMichael P Lisanti
Jan 18, 2006·Cardiovascular Research·Carsten SchwenckeRuth H Strasser
Feb 8, 2006·Nature Reviews. Genetics·Hugh Watkins, Martin Farrall
May 5, 2007·Science·Ruth McPhersonJonathan C Cohen
Jul 20, 2007·The New England Journal of Medicine·Nilesh J SamaniUNKNOWN WTCCC and the Cardiogenics Consortium
Jan 15, 2008·Nature Genetics·Cristen J WillerGonçalo R Abecasis
May 30, 2008·American Journal of Physiology. Cell Physiology·Philippe G FrankMichael P Lisanti
Aug 16, 2008·Heart·X-H ZhangL Liu
Oct 17, 2008·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Jijin LinWencan Xu
Feb 10, 2009·Nature Genetics·UNKNOWN Myocardial Infarction Genetics ConsortiumDavid Altshuler
Feb 10, 2009·Nature Genetics·Daniel F GudbjartssonKari Stefansson
Feb 10, 2009·Nature Genetics·Jeanette ErdmannHeribert Schunkert
Dec 3, 2009·JAMA : the Journal of the American Medical Association·Janet M TorpyRichard M Glass
Jan 12, 2010·Nature Genetics·Arne PfeuferSusan R Heckbert
Jan 12, 2010·Nature Genetics·Hilma HolmKari Stefansson
Jan 13, 2010·Clinica Chimica Acta; International Journal of Clinical Chemistry·Xiang RenQing Kenneth Wang
Jun 29, 2010·The American Journal of Pathology·Carlos Fernández-HernandoWilliam C Sessa
Mar 8, 2011·Nature Genetics·UNKNOWN Coronary Artery Disease (C4D) Genetics Consortium
May 27, 2011·The Journal of Clinical Endocrinology and Metabolism·Luminita H PojogaGordon H Williams
Jul 29, 2011·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·David EngelEsther Lutgens
Aug 31, 2011·Human Molecular Genetics·John F Peden, Martin Farrall
May 1, 2012·Nature Genetics·Patrick T EllinorStefan Kääb
Jun 5, 2012·Journal of Molecular and Cellular Cardiology·Andrea BarbutiDario Difrancesco
Jan 19, 2013·Journal of Thrombosis and Thrombolysis·Jiangfang LianShiwei Duan
Feb 4, 2014·Journal of the American College of Cardiology·Steven A LubitzPatrick T Ellinor
Sep 10, 2014·Pacing and Clinical Electrophysiology : PACE·Yaowu LiuFengxiang Zhang
May 9, 2015·Journal of the American Heart Association·Shanshan ChenQing K Wang

❮ Previous
Next ❯

Citations

May 16, 2018·Metabolic Syndrome and Related Disorders·Gustavo Mora-GarcíaClaudio Gómez-Alegría
Aug 11, 2020·Current Opinion in Lipidology·Xinbo Zhang, Carlos Fernández-Hernando
Jan 10, 2019·Frontiers in Genetics·Rasheeba NizamFahd Al-Mulla
Oct 24, 2019·Nature Communications·Kristjan NorlandKari Stefansson
Feb 23, 2020·Oxidative Medicine and Cellular Longevity·Dania HaddadFahd Al-Mulla
Dec 7, 2020·Clinica Chimica Acta; International Journal of Clinical Chemistry·Kai HouXuping Qin
Oct 31, 2020·Molecular Biology Reports·Gabriela Montenegro de SouzaJaqueline de Azevêdo Silva
Jun 23, 2021·The British Journal of Nutrition·Faezeh Abaj, Khadijeh Mirzaei
Aug 7, 2021·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Atieh MirzababaeiKhadijeh Mirzaei
Sep 18, 2021·BMC Cardiovascular Disorders·Long LiuHaiming Xu

❮ Previous
Next ❯

Related Concepts

Related Feeds

ApoE Phenotypes

Apolipoprotein E (APOE) is a protein involved in fat metabolism and associated with the pathogenesis of Alzheimer's disease and cardiovascular disease. Here is the latest research on APOE phenotypes.

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.

Caveolins & Signal Transduction

Caveolins are small proteins with a hairpin loop conformation that are located in the plasma membrane of various cell types where they bind cholesterol and interact with receptors essential for several signal transduction pathways. Here is the latest research.