Genomics and the ancient origins of the daptomycin biosynthetic gene cluster

The Journal of Antibiotics
Richard H Baltz

Abstract

Daptomycin is a clinically useful lipopeptide antibiotic produced by Streptomyces roseosporus. The antibiotic is assembled by a nonribosomal peptide synthetase (NRPS) mechanism, and the cyclized tridecapeptide contains three non-proteinogenic-amino acids: ornithine (Orn), 3-methyl-glutamic acid (3mGlu) and kynurinine (Kyn). Daptomycin also has three D-amino acids. The two genes that encode proteins involved in the formation of 3mGlu and Kyn have no known orthologs, and hence they are good probes to search for daptomycin-like gene clusters among newly sequenced actinomycete genomes. A recent search with these genes revealed a daptomycin-like gene cluster in Saccharomonospora viridis, a causative agent for farmer's lung disease. S. viridis has a genome of 4.3 Mb, which is about one half the size of Streptomyces genomes. Searches for other NRPS and polyketide synthase (PKS) genes revealed only one other NRPS gene and no PKS genes in S. viridis. The orthologous lipopeptide biosynthetic genes and gene products in S. viridis and S. roseosporus have diverged extensively from a last common ancestor dating back to a pathway that had evolved over 1 billion years ago.

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Citations

Aug 10, 2011·Journal of Industrial Microbiology & Biotechnology·Richard H Baltz
Nov 6, 2013·The Journal of Infection·John S Bradley
Jun 13, 2013·The Journal of Antibiotics·Julian Davies
Jul 5, 2013·Proceedings of the National Academy of Sciences of the United States of America·Jeremy G OwenSean F Brady
Nov 8, 2013·Journal of Industrial Microbiology & Biotechnology·Richard H Baltz
Dec 18, 2013·Journal of Industrial Microbiology & Biotechnology·Brian O BachmannRichard H Baltz
Sep 14, 2015·Journal of Industrial Microbiology & Biotechnology·Richard H Baltz
Oct 22, 2016·Annals of the New York Academy of Sciences·Boahemaa Adu-OppongGautam Dantas
Jan 26, 2017·The Journal of Antibiotics·Richard H Baltz
Dec 31, 2017·Journal of Industrial Microbiology & Biotechnology·Richard H Baltz
Nov 27, 2015·Microbiology and Molecular Biology Reviews : MMBR·Essaid Ait BarkaGilles P van Wezel
Nov 10, 2010·Natural Product Reports·Haoran ZhangBlaine A Pfeifer
Dec 24, 2019·Current Protein & Peptide Science·Xin XieHui Jiang
Sep 25, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Hiroshi Ogawara
Jan 19, 2021·Microbial Biotechnology·Zhiyong WuGuiyang Shi
Nov 5, 2020·International Journal of Environmental Research and Public Health·Sharon P NappierKaedra R Jones
Mar 20, 2021·Journal of Industrial Microbiology & Biotechnology·Richard H Baltz
Mar 19, 2021·EcoSal Plus·Nicholas WaglechnerGerard D Wright
Mar 6, 2018·Environmental Science & Technology·Ian L PepperCharles P Gerba

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