Genomics, morphogenesis and biophysics: triangulation of Purkinje cell development

The Cerebellum
Malcolm J Simons, András J Pellionisz

Abstract

The cerebellar Purkinje cells (P-cells) comprise an organelle that is suitable for combined analysis by morphology and genomics, using biophysical tools. In some unknown way, genomic information specifies the development of P-cells. One of us (AJP) has previously proposed that fractal processes associated with DNA are in a causal relation to the fractal properties of organelles such as P-cells (FractoGene, 2002, patent pending). This fractal postulate predicts that the dendritic arborization of P-cells will be less complex in lower order vertebrates. The prediction can be tested by systematic comparative neuroanatomy of the P-cell in species for which genome sequences permit inter-species comparison. The Fugu rubripes (Fugu), Danio rerio (Danio) and other species are lower order vertebrates for which genome sequences are available and tests could be conducted. Consistent with the fractal prediction, P-cell dendritic arbor is primitive in Fugu, being much less complex than in Mus musculus and in Homo sapiens. Genomic analysis readily identified PEP19/Pcp4, Calbindin-D28k, and GAD67 genes in Fugu and in Danio that are closely associated with P-cells in Canis familiaris, Rattus norvegicus, Mus musculus and Homo sapiens. Gene L7/Pc...Continue Reading

References

Jan 1, 1977·Neuroscience·A Pellionisz, R Llinás
Jan 1, 1990·Annals of the New York Academy of Sciences·J B BassingthwaighteR B King
Nov 25, 1994·Science·F Flam
Feb 21, 1993·Journal of Theoretical Biology·J L OliverR Román-Roldán
May 1, 1996·Nucleic Acids Research·C A Chatzidimitriou-DreismannD Larhammar
Jun 1, 1997·Brain Research. Molecular Brain Research·G VassilevaJ I Morgan
Dec 5, 1994·Physical Review Letters·R N MantegnaH E Stanley
Apr 4, 2000·Bioinformatics·J L OliverP Bernaola-Galván
Jul 26, 2003·The Cerebellum·Manuela M SantosMassimo Pandolfo
Oct 21, 2003·Scientific American·W Wayt Gibbs
Nov 25, 2003·Scientific American·W Wayt Gibbs
Jun 16, 2004·Scientific American·Nadrian C Seeman
Aug 7, 2004·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·Y TsunezukaH Minato
Aug 18, 2004·Neural Networks : the Official Journal of the International Neural Network Society·Ryu Nishimoto, Jun Tani
May 18, 2005·The Cerebellum·Mario-Ubaldo Manto
May 18, 2005·The Cerebellum·Arnulf H Koeppen

❮ Previous
Next ❯

Citations

Nov 13, 2007·Analytical and Bioanalytical Chemistry·M González-FernándezJ L Gómez-Ariza
Feb 24, 2011·Biological Trace Element Research·Lu ZhangZu Pei Chen
Jun 21, 2008·The Cerebellum·Andras J Pellionisz
Sep 5, 2008·The Cerebellum·Rui ZhangJohn Oberdick
Aug 30, 2008·Brain Research·Daniela NecchiElda Scherini
Oct 22, 2008·Molecular and Cellular Neurosciences·Emilia IscruJohn Oberdick
Apr 6, 2007·Progress in Neurobiology·Randal X MoldrichMarie-Claude Potier
Nov 17, 2009·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Byung Joo KimJu-Hong Jeon
Apr 7, 2007·The Nurse Practitioner·Susan Simmons Holcomb

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.