Genomics of Clostridium taeniosporum, an organism which forms endospores with ribbon-like appendages

PloS One
Joshua M CambridgeJames R Walker

Abstract

Clostridium taeniosporum, a non-pathogenic anaerobe closely related to the C. botulinum Group II members, was isolated from Crimean lake silt about 60 years ago. Its endospores are surrounded by an encasement layer which forms a trunk at one spore pole to which about 12-14 large, ribbon-like appendages are attached. The genome consists of one 3,264,813 bp, circular chromosome (with 26.6% GC) and three plasmids. The chromosome contains 2,892 potential protein coding sequences: 2,124 have specific functions, 147 have general functions, 228 are conserved but without known function and 393 are hypothetical based on the fact that no statistically significant orthologs were found. The chromosome also contains 101 genes for stable RNAs, including 7 rRNA clusters. Over 84% of the protein coding sequences and 96% of the stable RNA coding regions are oriented in the same direction as replication. The three known appendage genes are located within a single cluster with five other genes, the protein products of which are closely related, in terms of sequence, to the known appendage proteins. The relatedness of the deduced protein products suggests that all or some of the closely related genes might code for minor appendage proteins or asse...Continue Reading

References

Jan 1, 1991·Annual Review of Genetics·G G Wilson, N E Murray
Apr 5, 1990·Nature·D H Bamford, J K Bamford
Mar 25, 1986·Nucleic Acids Research·R C Wek, G W Hatfield
Mar 1, 1988·Journal of Bacteriology·E DubnauI Smith
Jan 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·W M ChingT C Stadtman
May 1, 1971·CRC Critical Reviews in Microbiology·L J Rode
Aug 21, 1972·Journal of Molecular Biology·E N Jackson, C Yanofsky
Feb 1, 1973·Journal of Bacteriology·R E YasbinF E Young
Jan 1, 1968·Biopolymers·G N RamachandranE R Blout
Mar 1, 1967·Journal of Bacteriology·L J RodeM G Williams
Dec 1, 1984·Cell·I Katsura, R W Hendrix
Jan 1, 1981·Annual Review of Biochemistry·H A Barker
Mar 1, 1983·Archives of Biochemistry and Biophysics·G L Dilworth
Oct 1, 1994·International Journal of Systematic Bacteriology·M D CollinsJ A Farrow
May 3, 1996·Science·J R Lobry
May 17, 1996·Science·A M Deshpande, C S Newlon
May 1, 1996·Molecular Biology and Evolution·J R Lobry
Sep 1, 1997·Nucleic Acids Research·S F AltschulD J Lipman
Sep 5, 1997·Science·F R BlattnerY Shao
Oct 23, 1997·Journal of Bacteriology·M H QinM Rajagopalan
May 16, 1998·Genome Research·D GordonP Green
Sep 2, 1998·Journal of Structural Biology·K Beck, B Brodsky
Nov 18, 1998·FEMS Microbiology Reviews·M M Wösten
Dec 11, 1999·Nucleic Acids Research·R L TatusovE V Koonin
Mar 8, 2000·BioFactors·A Böck
Jun 6, 2000·Microbiology and Molecular Biology Reviews : MMBR·N E Murray
Jun 22, 2000·Proceedings of the National Academy of Sciences of the United States of America·W T Self, T C Stadtman
Apr 27, 2002·The Journal of Biological Chemistry·Yi XuSlawomir Lukomski
Jul 24, 2002·Nucleic Acids Research·Kazutaka KatohTakashi Miyata
Aug 10, 2002·Journal of Bacteriology·Robert A BrittonAlan D Grossman
Dec 31, 2003·Journal of Molecular Biology·Jonas EmsleyMichael J Barnes

❮ Previous
Next ❯

Citations

Apr 20, 2021·ACS Biomaterials Science & Engineering·Yimin QiuJingjie Yeo
Jun 20, 2019·Microbiology Spectrum·Robert J Moore, Jake A Lacey

❮ Previous
Next ❯

Datasets Mentioned

BETA
CP017255

Methods Mentioned

BETA
scanning electron microscopy
electron microscopy
transmission electron microscopy
PCR

Software Mentioned

Lalign
Consed
MAFFT
MyHits
Internal Repeats Finder
GeneMarkS
Geneious Pro
Geneious
Photoshop
Pattern Locator

Related Concepts

Related Feeds

Botulism (ASM)

Botulism is a rare but serious paralytic illness caused by a nerve toxin that is produced by the bacterium clostridium botulinum. Discover the latest research on botulism here.

Anthrax

Anthrax toxin, comprising protective antigen, lethal factor, and oedema factor, is the major virulence factor of Bacillus anthracis, an agent that causes high mortality in humans and animals. Here is the latest research on Anthrax.

Bacillus Cereus Infection

Bacillus Cereus is a gram-positive bacteria that is the cause of some foodborne illnesses and leads to diarrhea and vomiting. Discover the latest research on Bacillus Cereus Infection here.

Anthrax Vaccines

Three different types of anthrax vaccines are available; a live-attenuated, an alum-precipitated cell-free filtrate and a protein recombinant vaccine. The effectiveness between the three is uncertain, but the live-attenuated have shown to reduce the risk of anthrax with low adverse events. Here is the latest research on anthrax vaccines.

Botulism

Botulism is a rare but serious paralytic illness caused by a nerve toxin that is produced by the bacterium clostridium botulinum. Discover the latest research on botulism here.

Bacteriophage: Phage Therapy

Phage therapy uses bacterial viruses (bacteriophages) to treat bacterial infections and is widely being recognized as an alternative to antibiotics. Here is the latest research.

Anthrax Vaccines (ASM)

Three different types of anthrax vaccines are available; a live-attenuated, an alum-precipitated cell-free filtrate and a protein recombinant vaccine. The effectiveness between the three is uncertain, but the live-attenuated have shown to reduce the risk of anthrax with low adverse events. Here is the latest research on anthrax vaccines.