Genomics of hypertension

Pharmacological Research : the Official Journal of the Italian Pharmacological Society
S PadmanabhanA F Dominiczak

Abstract

A complex network of interacting pathways involving renal, neural, endocrine, vascular and other mechanisms controls the main determinants of blood pressure - cardiac output and total peripheral resistance. Multiple genes within each of these systems contribute to the specialized functions regulating blood pressure. The monogenic forms of blood pressure dysregulation have provided valuable insights into blood pressure regulation and expanded our understanding of both the mechanisms and the treatment of hypertension. Genome wide association studies have identified over 100 single nucleotide polymorphisms associated with blood pressure phenotypes and have identified plausible novel pathways of BP regulation and putative drug targets.

References

Jul 1, 1986·The Journal of Clinical Investigation·F Murad
Jan 1, 1986·Clinical and Experimental Hypertension. Part A, Theory and Practice·J G MongeauC F Sing
Jan 1, 1986·Journal of Chronic Diseases·S C HuntG K Barlow
Dec 1, 1972·Annals of Biomedical Engineering·A C GuytonR D Manning
Oct 25, 1996·Science·E S Lander
Jun 23, 1999·Proceedings of the National Academy of Sciences of the United States of America·N MatsukawaO Smithies
Mar 10, 2001·Cell·R P LiftonD S Geller
Aug 11, 2001·Science·F H WilsonR P Lifton
Jun 27, 2003·Lancet·Mark CaulfieldUNKNOWN MRC British Genetics of Hypertension Study
Sep 1, 1955·Annals of Internal Medicine·G W PICKERING
May 29, 2004·Molecular Microbiology·David A Baker, John M Kelly
Aug 18, 2004·Journal of Hypertension·Cristiano FavaOlle Melander
Nov 24, 2004·Hypertension·Nina KupperEco J C de Geus
Apr 25, 2007·Proceedings of the National Academy of Sciences of the United States of America·Andreas FriebeDoris Koesling
May 12, 2009·Nature Genetics·Daniel LevyCornelia M van Duijn
May 12, 2009·Nature Genetics·Christopher Newton-ChehPatricia B Munroe
Oct 9, 2009·Nature·Teri A ManolioPeter M Visscher
Nov 4, 2010·Journal of Hypertension·Jennifer E HoDaniel I Chasman
Nov 10, 2010·Hypertension·Xiaoling Wang, Harold Snieder
Jun 22, 2011·Kidney & Blood Pressure Research·Carsten A Böger, Iris M Heid
Sep 3, 2011·Nature·Karsten SuhreChristian Gieger
Sep 13, 2011·Nature·UNKNOWN International Consortium for Blood Pressure Genome-Wide Association StudiesToby Johnson
Mar 20, 2013·Hypertension·Sandosh Padmanabhan
Jul 23, 2013·The Journal of Clinical Investigation·Pankaj AroraThomas J Wang

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Citations

Dec 14, 2018·Nature Reviews. Neurology·Frederick A ZeilerDavid K Menon
Oct 26, 2018·Expert Review of Cardiovascular Therapy·Tarun SaxenaManjari Saxena
Mar 29, 2018·Current Hypertension Reports·J C Yugar-ToledoH Moreno
Dec 22, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Wesam S AhmedKabir H Biswas
Jun 17, 2020·American Journal of Obstetrics and Gynecology·Mary Catherine TolcherMichael A Belfort

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