PMID: 30027934Jul 22, 2018Paper

Genomics of neuroendocrine tumors of the lung and gastrointestinal tract: similarities and differences

Magyar onkologia
József Tímár, Attila Patócs

Abstract

The incidence of neuroendocrine tumors sharply increased in the past years. It is also important that beside the relatively benign, slow growing tumors, prevalence of aggressive neuroendocrine carcinomas is also increasing. It is now evident that the carcinoids are genetically heterogeneous entities, localized to lung, pancreas or to the small intestines. A significant proportion of these neuroendocrine tumors are associated with hereditary syndromes but the etiology of the sporadic versions is still unknown, although in case of the lung, neuroendocrine carcinomas have a similar etiology than the non-endocrine carcinomas. This review summarizes the results of recent complex genomic analyses. Based on these data it is evident that the neuroendocrine tumors of the lung are different as compared to gastrointestinal ones. These genetic differences may fundamentally affect their biology, prognosis and therapy which must be considered.

Related Concepts

Related Feeds

Cancer Genomics (Keystone)

Cancer genomics approaches employ high-throughput technologies to identify the complete catalog of somatic alterations that characterize the genome, transcriptome and epigenome of cohorts of tumor samples. Discover the latest research using such technologies in this feed.

Related Papers

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Hans Scherübl
The American Journal of Gastroenterology
J A SterlingM Galvez
Surgery, Gynecology & Obstetrics
R J SANDERS, H K AXTELL
American Journal of Clinical Pathology
M B DOCKERTY
© 2022 Meta ULC. All rights reserved