Jul 18, 2017

Genomics of Systemic Lupus Erythematosus: Insights Gained by Studying Monogenic Young-Onset Systemic Lupus Erythematosus

Rheumatic Diseases Clinics of North America
Linda T Hiraki, Earl D Silverman

Abstract

Systemic lupus erythematosus (SLE) is a systemic, autoimmune, multisystem disease with a heterogeneous clinical phenotype. Genome-wide association studies have identified multiple susceptibility loci, but these explain a fraction of the estimated heritability. This is partly because within the broad spectrum of SLE are monogenic diseases that tend to cluster in patients with young age of onset, and in families. This article highlights insights into the pathogenesis of SLE provided by these monogenic diseases. It examines genetic causes of complement deficiency, abnormal interferon production, and abnormalities of tolerance, resulting in monogenic SLE with overlapping clinical features, autoantibodies, and shared inflammatory pathways.

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Mentioned in this Paper

Interferon Production
Genome-Wide Association Study
Pathogenic Aspects
Biochemical Pathway
Autoantibodies
Pathogenesis
Multisystem Disorder
Genomics
Disease Susceptibility
Interferons

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