Mar 25, 2020

Improved segmentation of the intracranial and ventricular volumes in populations with cerebrovascular lesions and atrophy using 3D CNNs

BioRxiv : the Preprint Server for Biology
E. E. NtiriJ. Ramirez

Abstract

Successful segmentation of the total intracranial vault (ICV) and ventricles is of critical importance when studying neurodegeneration through neuroimaging. We present iCVMapper and VentMapper, robust algorithms that use a convolutional neural network (CNN) to segment the ICV and ventricles from both single contrast and multi-contrast MRI data. Our models were trained on a large dataset from two multi-site studies (N=528 subjects for ICV, N=501 for ventricular segmentation) consisting of older adults with varying degrees of cerebrovascular lesions and atrophy, posing significant challenges for most segmentation approaches. The models were tested on 132 participants, including subjects with high white matter hyperintensity burden from a third multi-site study not used in the training dataset. We assessed our algorithms relative to four state-of-the-art ICV extraction methods (MONSTR, BET, Deep Extraction, Freesurfer), as well as an open source ventricular segmentation tool (Freesurfer). Our multi-contrast models outperformed other methods across all evaluation metrics, with an average Dice coefficient of 0.98 and 0.94 for ICV and ventricular segmentation respectively. Both models were also the most time efficient, segmenting the...Continue Reading

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Mentioned in this Paper

Bounded by
Genome
Genomics
Optical Methods
Optical Restriction Mapping
Analysis
Computed (Procedure)
DNA
Molecular Assembly/Self Assembly

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