Genoprotective and hepatoprotective effects of Guarana (Paullinia cupana Mart. var. sorbilis) on CCl4-induced liver damage in rats

Drug and Chemical Toxicology
Helena KoberRafael Noal Moresco

Abstract

Several biological effects of Paullinia cupana (guarana) have been demonstrated, but little information is available on its effects on the liver. The current study was designed to evaluate the hepatoprotective and genoprotective effects of powder seeds from guarana on CCl4-induced liver injury in rats. Male Wistar rats were pretreated with guarana powder (100, 300 and 600 mg/kg) or silymarin 100 mg/kg daily for 14 days before treatment with a single dose of CCl4 (50% CCl4, 1 mL/kg, intraperitoneally). The treatment with CCl4 significantly increased the serum activities of alanine aminotransferase (ALT) and aspartate aminotransferase (AST). In addition, CCl4 increased the DNA damage index in hepatocytes. Guarana in all concentrations was effective in decreasing the ALT and AST activities when compared with the CCl4-treated group. The treatment with guarana decreased DNA damage index when compared with the CCl4-treated group. In addition, the DNA damage index showed a significant positive correlation with AST and ALT. These results indicate that the guarana has hepatoprotective activity and prevents the DNA strand breakage in the CCl4-induced liver damage in rats.

References

Jan 1, 1989·Pharmacology & Therapeutics·R O RecknagelR L Waller
Mar 1, 1988·Experimental Cell Research·N P SinghE L Schneider
May 1, 1985·Zeitschrift Für Lebensmittel-Untersuchung Und -Forschung·F BelliardoM G Valle
Feb 1, 1997·Journal of Ethnopharmacology·E B EspinolaE A Carlini
Feb 18, 1999·Toxicology Letters·V BohrG Dianov
Mar 29, 2000·Environmental and Molecular Mutagenesis·R R TiceY F Sasaki
Apr 25, 2001·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·C N BoozerJ L Solomon
Aug 21, 2001·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·S B NadinD R Ciocca
Aug 23, 2001·Proceedings of the National Academy of Sciences of the United States of America·M L HamiltonA Richardson
Nov 29, 2002·International Journal of Hygiene and Environmental Health·Nachman Brautbar, John Williams
Dec 11, 2002·Mutagenesis·A HartmannUNKNOWN 4th International Comet Assay Workshop
Apr 24, 2003·Critical Reviews in Toxicology·Lutz W D WeberAndreas Stampfl
Feb 8, 2005·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·E Porchezhian, S H Ansari
Jul 26, 2005·Journal of Ethnopharmacology·Adriana BasileDomenico Montesano
Jan 13, 2006·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·H FukumasuM L Z Dagli
Mar 14, 2007·Journal of Applied Toxicology : JAT·Rajat Kumar DasSudin Bhattacharya
Oct 26, 2007·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Elza Yamaguti-SasakiJoão Carlos Palazzo de Mello
Nov 30, 2007·Chemico-biological Interactions·Hui-Mei LinFen-Pi Chou
Feb 29, 2008·The American Journal of Chinese Medicine·Sung Hyun LeeMyeong-Hyeon Wang
Dec 28, 2010·Clinical Biochemistry·Etiane TatschRafael Noal Moresco
Jan 12, 2011·Proceedings of the National Academy of Sciences of the United States of America·Sandy VanderauweraRon Mittler
Dec 12, 2012·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·L S BittencourtI B M Cruz
Jul 24, 2013·Critical Reviews in Toxicology·Edward J Calabrese
Aug 29, 2013·Journal of Ethnopharmacology·Flávia Camila SchimplPaulo Mazzafera

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Citations

Nov 21, 2019·Nutrición hospitalaria·Renato de Souza AbboudMauricio Alves Chagas
Jun 26, 2018·Laboratory animal research·Jae Young YuJong Oh Kim
Mar 1, 2018·Comprehensive Reviews in Food Science and Food Safety·Xiao MengHua-Bin Li
Nov 24, 2019·Colloids and Surfaces. B, Biointerfaces·Isabel RoggiaPatrícia Gomes
May 31, 2021·Neurochemistry International·Charles Elias AssmannIvana Beatrice Mânica da Cruz
Aug 26, 2021·Journal of Medicinal Food·Emerson Barbosa da SilvaBeatriz da Costa Aguiar Alves

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