Genotoxic and Cytotoxic Effects in Exfoliated Buccal and Nasal Cells of Chromium and Cobalt Exposed Electroplaters

Journal of Toxicology and Environmental Health. Part a
Georg WultschSiegfried Knasmüller

Abstract

Results of a number of studies indicate that electroplaters have increased cancer risks as a consequence of exposure to genotoxic metals such as chromium (VI) and nickel. These effects may be due to induction of damage of the genetic material which plays a key role in the etiology of cancer, and it was found that workers in galvanization factories exhibited increased levels of DNA damage. The aim of the present study was to investigate genetic stability in workers of a bright plating factory who are exposed to chromium (Cr) and cobalt (Co). Exfoliated cells were collected from the buccal and nasal mucosa of workers (n = 42) and matched controls (n = 43) and analyzed for induction of micronuclei (MN) which are formed as a consequence of chromosomal aberrations. In addition, other nuclear anomalies namely nuclear buds (Nbuds) which are formed as a consequence of gene amplification and markers indicating different stages of cell death (condensed chromatin, karyorrhexis, karyolysis, and pyknosis) were also assessed. No evidence was noted for induction of MN, but significantly increased rates of Nbuds in cells from both, buccal and nasal mucosa, were found. Parameters which are indicative for cytotoxic effects were more pronounced i...Continue Reading

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Citations

Mar 29, 2018·Journal of Toxicology and Environmental Health. Part a·Duck Soo LimByung-Mu Lee
Oct 10, 2019·Journal of Toxicology and Environmental Health. Part a·Georg WultschSiegfried Knasmüller
Jan 15, 2021·Clinical, Cosmetic and Investigational Dermatology·Nazeer Hussain KhanXin-Ying Ji

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electrophoresis

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