Genotoxic and cytotoxic effects of carbofuran and furadan on Chinese hamster ovary (CHOK1) cells

Mutation Research
Sonia SoloneskiMarcelo L Larramendy

Abstract

The in vitro geno- and cytotoxicity exerted by the N-methylcarbamate pesticide carbofuran (CF) and its commercial formulation furadan (F) were studied in Chinese hamster ovary (CHO(K1)) cells by several bioassays for both genotoxicity (e.g., the sister chromatid exchange (SCE) and micronuclei (MNi) frequencies), and cytotoxicity (e.g., cell-cycle progression, mitotic index (MI), 3(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT), and neutral red (NR)). Both CF and F activities were tested within the range of 5-100 microg/ml. CF within a 10-100 microg/ml concentration-range induced a significant dependent increase of SCE frequency and MNi over control values. At the same concentration-range, F increased significantly the SCE frequencies over control values although in a non-dependent manner while only an enhanced frequency of MNi was found in those 50 microg/ml-treated cultures. No binucleated cytokinesis-block cells were found in 100 microg/ml F-treated cultures. The NDI index revealed a delay in the onset of cell-division with 50 and 100 microg/ml of CF and F, respectively. The delayed rate of nuclear division induced by 100 microg/ml of F was higher than that induced by an equal concentration of CF. CF and F in...Continue Reading

References

Aug 1, 1976·Mutation Research·J D ReganW Lijinsky
Jul 1, 1977·Mutation Research·R D BlevinsJ D Regan
May 1, 1983·Mutation Research·L LambertiG Ardito
Dec 1, 1994·Journal of Toxicology and Environmental Health·R C Gupta
Jul 24, 1998·Neurochemistry International·A Karczmar
Dec 13, 2000·Mutation Research·M Fenech
Jun 21, 2002·Toxicological Sciences : an Official Journal of the Society of Toxicology·Rhonda M Brand, Cynthia Mueller
Jul 30, 2005·Drug and Chemical Toxicology·Rambabu Naravaneni, Kaiser Jamil
Mar 11, 2006·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Davor ZeljezicPetra Perkovic
Jan 12, 2007·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Chih-Min LinTsing-Cheng Wang
May 18, 2007·Journal of Nippon Medical School = Nippon Ika Daigaku Zasshi·Qing Li
Aug 4, 2007·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Davor ZeljezićNevenka Kopjar

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Citations

Jul 1, 2015·Environmental Science and Pollution Research International·Ali S Al-SararHamdy I Hussein
Mar 10, 2010·Environmental and Molecular Mutagenesis·Ofelia A OliveroGraciela Spivak
Oct 23, 2013·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Noelia NikoloffMarcelo L Larramendy
Jan 8, 2014·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Noelia NikoloffSonia Soloneski
Nov 15, 2011·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Noelia NikoloffMarcelo L Larramendy
Mar 30, 2010·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·E MaranM J Ruiz
Jan 8, 2015·Toxicological Sciences : an Official Journal of the Society of Toxicology·Ozgur CinarAlp Can
Feb 8, 2021·Environmental Science and Pollution Research International·Noelia NikoloffCecilia C Furnus
Jul 27, 2021·Frontiers in Microbiology·Harshit MalhotraPrashant S Phale

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