Genotoxic and mutagenic effects of Atrazine Atanor 50 SC on Dendropsophus minutus Peters, 1872 (Anura: Hylidae) developmental larval stages

Chemosphere
M W GonçalvesDaniela de Melo E Silva

Abstract

The potential mutagenic and genotoxic effects of the herbicide atrazine were investigated in different developmental stages of Dendropsophus minutus tadpoles. These animals were exposed to 4 nominal concentrations of atrazine (2.25, 4.5, 9, and 18 mg/L) and 40 mg/L of Cyclophosphamide as a positive control, for 96 h. Negative controls were also added to the experiment. The tadpoles were divided into three groups according to Gosner's developmental stages, namely GS 25-33 as premetamorphic, GS 36-39 as prometamorphic, and GS 42-43 as metamorphic climax. Our results showed that the premetamorphic and metamorphic stages were more sensitive than the prometamorphic stage to the herbicide. A comet assay and micronucleus test for the sensitive stages demonstrated DNA damage in a concentration-dependent curve. Although a dose-response effect was not observed for the prometamorphic stage, a statistically significant difference was found between the treatment of 18 mg/L and the negative control. Moreover, the highest concentration of atrazine showed both the largest amount of DNA damage and the highest micronucleus frequency regardless of the developmental stage of D. minutus. In conclusion, atrazine was genotoxic and mutagenic for D. mi...Continue Reading

Citations

Apr 6, 2019·Archives of Environmental Contamination and Toxicology·Rinneu Elias BorgesClassius de Oliveira
Jul 6, 2020·Environmental Science and Pollution Research International·Felipe de Araújo NascimentoDaniela de Melo E Silva
Jun 27, 2019·Archives of Environmental Contamination and Toxicology·Macks Wendhell GonçalvesDaniela de Melo E Silva
Nov 27, 2018·Environmental Science and Pollution Research International·Rinneu Elias BorgesClassius de Oliveira
Nov 7, 2019·Environmental Monitoring and Assessment·Shagufta BibiAzizullah Azizullah
Jan 8, 2021·Environmental Science and Pollution Research International·Flavia Isabelli Dos SantosElisângela Düsman
Jan 2, 2021·Environmental Pollution·Wadson Rodrigues RezendeClassius De Oliveira
Jun 17, 2018·Chemico-biological Interactions·Alzbeta StaraJosef Velisek

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