PMID: 11932004Apr 5, 2002Paper

Genotoxic, cytotoxic and ontogenetic effects of tri-n-butyltin on the marine worm, Platynereis dumerilii (Polychaeta: Nereidae)

Aquatic Toxicology
Josephine A HaggerAwadhesh N Jha

Abstract

The genotoxic, cytotoxic and ontogenetic (embryo-larval) or developmental effects of tri-n-butyltin (TBT), were investigated in Platynereis dumerilii. Following the determination of maximum tolerated dose with regard to ontogenetic effects and mortality, early life stages of P. dumerilii were exposed to a range of TBT concentrations. Subsequently, the embryo-larvae were analysed for evidence of genotoxicity and cytotoxicity. Genotoxicity was assessed using cytogenetic endpoints that included the frequency of sister chromatid exchanges and chromosomal aberrations from metaphase spreads. Cytotoxicity was evaluated by determining the proliferative rate index of the growing embryo-larval cells using 5-bromodeoxyuridine labelling of the chromosomes or fluorescence plus Giemsa staining technique. TBT-exposed embryo-larvae of P. dumerilii exhibited sensitivity similar to that of other invertebrates, indicating that P. dumerilii is a suitable ecotoxicity test species. The results also suggested dose-dependent effects for genotoxic and cytotoxic end points in relation to TBT exposure. The present study highlights the need to elucidate the relative importance of direct genotoxic and indirect effects through production of genotoxic hormon...Continue Reading

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Citations

Apr 12, 2013·Biofouling·Pei-Yuan QianYing Xu
Jul 31, 2003·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Jeanette M Rotchell, Gary K Ostrander
Jul 5, 2006·Environmental Health Perspectives·Josephine A HaggerTamara S Galloway
Feb 12, 2014·The Science of the Total Environment·Javier García-AlonsoPhilip S Rainbow
Jan 24, 2016·Chemosphere·Pearl U OfoegbuJoão L T Pestana
Aug 30, 2011·Marine Environmental Research·Ceri Lewis, Gordon J Watson
Jul 20, 2011·Fish & Shellfish Immunology·Xiwei JiaZiping Zhang
Feb 16, 2012·Journal of Applied Toxicology : JAT·Tsu-Fan ChengKristi Muldoon-Jacobs
Aug 2, 2005·Marine Pollution Bulletin·Josephine A HaggerTamara S Galloway
Sep 9, 2004·Mutation Research·Awadhesh N Jha
Jun 27, 2008·Mutation Research·Ceri Lewis, Tamara Galloway

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