Genotoxic Effect in Autoimmune Diseases Evaluated by the Micronucleus Test Assay: Our Experience and Literature Review

BioMed Research International
Olivia Torres-BugarínMaría Guadalupe Zavala-Cerna

Abstract

Autoimmune diseases (AD) are classified into organ-specific, systemic, and mixed; all forms of AD share a high risk for cancer development. In AD a destructive immune response induced by autoreactive lymphocytes is started and continues with the production of autoantibodies against different targets; furthermore apoptosis failure and loss of balance in oxidative stress as a consequence of local or systemic inflammation are common features seen in AD as well. Micronucleus (MN) assay can be performed in order to evaluate loss of genetic material in a clear, accurate, fast, simple, and minimally invasive test. The MN formation in the cytoplasm of cells that have undergone proliferation is a consequence of DNA fragmentation during mitosis and the appearance of small additional nuclei during interphase. The MN test, widely accepted for in vitro and in vivo genotoxicity research, provides a sensitive marker of genomic damage associated to diverse conditions. In here, we present a review of our work and other published papers concerning genotoxic effect in AD, identified by means of the MN assay, with the aim of proposing this tool as a possible early biomarker for genotoxic damage, which is a consequence of disease progression. Addit...Continue Reading

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Citations

Jun 15, 2016·Biochemistry. Biokhimii︠a︡·O P Kisurina-EvgenievaG E Onishchenko
Nov 28, 2018·Mutagenesis·Olgica MihaljevicSlavica Markovic
Feb 28, 2020·International Journal of Molecular Sciences·Sylwester SommerMarcin Kruszewski
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Oct 28, 2021·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Manal A HamedAli M El-Hagrassi

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Methods Mentioned

BETA
chromosomal aberrations

Software Mentioned

ProQuest

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