Genotoxic effects of occupational exposure to benzene in gasoline station workers

Industrial Health
Eman SalemMofrih Hegazy

Abstract

Benzene, a hazardous component of gasoline, is a genotoxic class I human carcinogen. This study evaluated the genotoxic effects of occupational exposure to benzene in gasoline stations. Genotoxicity of exposure to benzene was assessed in peripheral blood leucocytes of 62 gasoline station workers and compared with an equal numbers of matched controls using total genomic DNA fragmentation, micronucleus test and cell viability test. An ambient air samples were collected and analyzed for Monitoring of benzene, toluene, ethyl benzene and xylene (BTEX) in work environment and control areas. DNA fragmentation, micronucleus and dead cells percent were significantly higher in exposed workers than controls. Level of benzene, Toluene, Ethyl benzene and xylene in the work environment were higher than the control areas and the permissible limits. Gasoline station workers occupationally exposed to benzene are susceptible to genotoxic effects indicated by increased DNA fragmentation, higher frequency of micronucleus and decreased leukocytes viability.

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Citations

Jan 4, 2020·Environmental and Molecular Mutagenesis·Anqi LiZhao-Lin Xia
Dec 20, 2019·BMC Pharmacology & Toxicology·Angela Maria MoroSolange Cristina Garcia
Mar 15, 2020·Environmental Science and Pollution Research International·Alaa A RizkRagaa M El-Gazzar
Nov 17, 2020·Frontiers in Genetics·Temitope H AdebamboAdebayo A Otitoloju
Apr 19, 2021·Mutation Research. Genetic Toxicology and Environmental Mutagenesis·Katia Soares da PoçaMarcia Sarpa

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Methods Mentioned

BETA
chromosomal aberrations
electrophoresis

Software Mentioned

SPSS Statistics
ImageJ

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