PMID: 7523918Oct 1, 1994Paper

Genotoxic effects of the o-phenylphenol metabolites phenylhydroquinone and phenylbenzoquinone in V79 cells

Mutation Research
A C Lambert, D A Eastmond

Abstract

o-Phenylphenol (OPP) and its sodium salt, sodium o-phenylphenate are broad spectrum fungicides and disinfectants with widespread usage. Both chemicals have been reported to induce cancer in the kidney and urinary bladder of Fischer 344 rats. Recently it has been proposed that the metabolic activation of OPP occurs via a two-step process involving the cytochrome P450-mediated formation of phenylhydroquinone (PHQ) in the liver and a prostaglandin H synthase-mediated oxidation of PHQ to phenylbenzoquinone (PBQ) in the urinary tract. In order to further investigate the metabolic activation and genotoxic effects of OPP, we have investigated the ability of PHQ and PBQ to induce micronuclei and mutations at the HGPRT locus in a prostaglandin H synthase-containing V79 Chinese hamster lung fibroblast cell line. In arachidonic acid-supplemented V79 cells, PHQ induced a significant increase in micronuclei whereas no increase was observed in cells in the absence of arachidonic acid supplementation. Immunofluorescent labeling of centromeric proteins with the CREST antibody indicated that the arachidonic acid-dependent induction of micronuclei by PHQ was due almost entirely to micronuclei containing whole chromosomes which had failed to segr...Continue Reading

References

May 1, 1989·Mutation Research·S TayamaY Nakagawa
Jan 1, 1986·Environmental Mutagenesis·K MortelmansE Zeiger
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Citations

Feb 27, 2016·Environmental and Molecular Mutagenesis·S BalakrishnanD A Eastmond
Apr 20, 2006·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·S Balakrishnan, D A Eastmond
Feb 17, 2005·Environmental and Molecular Mutagenesis·David Brusick
Dec 19, 2002·Critical Reviews in Toxicology·E M BomhardM Richter
Apr 21, 2001·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·S OzawaY Ohno

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