Abstract
Sources of light beams such as white fluorescent light, are present in our daily life to meet the needs of life in the modern world. This study was conducted with the objective of determining the possible genotoxic, cytotoxic and aneugenic effects caused by this agent in different stages of the cell cycle (G0/early G1, S, and late G2), using different cytogenetic parameters (sister chromatid exchanges--SCE, chromosome aberrations--CA, and detection of aneugenic effects) in lymphocytes from temporary cultures of human peripheral blood. WFL showed a genotoxic effect in vitro, expressed by an increase in the frequency of SCE's, regardless of the cell cycle stage. However, no increase in the frequency of CAs was observed. In addition, disturbances in cell cycle kinetics and chromosomal segregation were also observed. Taken together, such data may contribute to a better understanding and a different management in the use of phototherapy for some pathological conditions.
References
Jul 15, 1978·Lancet·A L SchwartzS A Latt
Mar 1, 1979·Mutation Research·B S Hass, R B Webb
Feb 1, 1979·Mutation Research·R E Monticone, E L Schneider
May 1, 1979·Mutation Research·N H HatcherE B Hook
Apr 21, 1977·Nature·M O Bradley, N A Sharkey
Sep 13, 1974·Nature·P Perry, S Wolff
Mar 24, 1967·Science·H E Kubitschek
May 26, 1967·Science·R B Webb, M M Malina
Mar 1, 1995·Mutation Research·D M DeMariniL F Stankowski
Nov 1, 1995·Mutagenesis·I SbranaG Turchi
Apr 6, 1996·Mutation Research·F Y WuM Higurashi
May 14, 1996·Proceedings of the National Academy of Sciences of the United States of America·R P ParshadJ H Robbins
Oct 26, 1999·Transfusion·J G ChangC H Tsai
Jan 22, 2000·Journal of Photochemistry and Photobiology. B, Biology·K M JoyceB M Hannigan
May 20, 2000·Photochemistry and Photobiology·S SpechtM Leffak
Jul 29, 2000·Mutation Research·R J AlbertiniA Aitio
Jul 11, 2002·Mutation Research·A T Natarajan
Jul 11, 2002·Mutation Research·Micheline Kirsch-VoldersIlse Decordier
Nov 30, 2002·Experimental Eye Research·Narendra P SinghNorman S Wolf
Sep 1, 1960·Experimental Cell Research·P S MOORHEADD A HUNGERFORD
Dec 22, 2004·Progress in Retinal and Eye Research·Andreas WenzelCharlotte E Remé
Jul 27, 2005·Aquatic Toxicology·Josephine A HaggerAwadhesh N Jha
Nov 3, 2005·Acta Paediatrica·Ashima Madan
Nov 3, 2005·Experimental & Molecular Medicine·Sunyoung ChaeHyeseong Cho
Nov 23, 2006·Mutation Research·Fatma Funda Kaya, Mehmet Topaktaş
Dec 13, 2006·Mutation Research·David M Wilson, Larry H Thompson
Citations
Sep 14, 2012·Molecular Medicine·Bess LevinBernard Friedenson
Mar 27, 2010·BMC Cancer·Fernando S F GuimarãesEdvaldo S Trindade
Aug 25, 2009·BMC Cancer·Fernando S F GuimarãesDorly F Buchi
May 18, 2011·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Ceren Börçek KasurkaVedat Sekeroğlu