PMID: 2500337Jan 1, 1989Paper

Genotoxic potency of three quinoline compounds evaluated in vivo in mouse marrow cells

Environmental and Molecular Mutagenesis
A F McFee

Abstract

In vitro assays of the genotoxicity of quinoline compounds have yielded varying indications of their potency, and only limited determinations have been reported following in vivo administrations. We have quantified chromosome aberrations (CA) and sister chromatid exchanges (SCE) in the marrow cells of mice that had been injected with quinoline, 8-hydroxyquinoline, or 4-nitroquinoline-1-oxide up to levels approaching lethal. Treatments with quinoline produced no consistent increase in the number of aberrations at either 17 or 36 hr after treatment and no significant increase in SCE numbers at either 23 or 42 hr. Similarly, 8-hydroxyquinoline had no measurable effect on either CA or SCE but did tend to prolong the cell cycle. 4-Nitroquinoline-1-oxide was a very potent inducer of both CA and SCE as well as an inhibitor of cell division.

References

May 1, 1979·Mutation Research·Y Nakanishi, E L Schneider
Sep 1, 1978·Mutation Research·R J TrzosJ A Swenberg
Mar 1, 1979·Mutation Research·A MatsuokaM Ishidate
Jan 1, 1977·Mutation Research·J L EplerA A Hardigree
Jan 1, 1987·Environmental and Molecular Mutagenesis·J Ashby
Jan 1, 1986·Environmental Mutagenesis·B H MargolinE Zeiger
Oct 1, 1982·Mutation Research·M HayashiM Ishidate

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Citations

Jan 1, 1992·Teratogenesis, Carcinogenesis, and Mutagenesis·A AllavenaG Brambilla
Jan 18, 2016·Mutation Research. Genetic Toxicology and Environmental Mutagenesis·David KirklandRaffaella Corvi
Sep 27, 2015·Environmental and Molecular Mutagenesis·Daniel J RobertsLeon F Stankowski
Apr 18, 2012·Toxicology and Applied Pharmacology·Astrid A ReusCyrille A M Krul
Jan 1, 1993·Environmental and Molecular Mutagenesis·M D ShelbyR R Tice
Jan 1, 1995·Environmental and Molecular Mutagenesis·M D Shelby, K L Witt

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