Genotoxic potential of glyphosate formulations: mode-of-action investigations

Journal of Agricultural and Food Chemistry
William F HeydensDonna R Farmer

Abstract

A broad array of in vitro and in vivo assays has consistently demonstrated that glyphosate and glyphosate-containing herbicide formulations (GCHF) are not genotoxic. Occasionally, however, related and contradictory data are reported, including findings of mouse liver and kidney DNA adducts and damage following intraperitoneal (ip) injection. Mode-of-action investigations were therefore undertaken to determine the significance of these contradictory data while concurrently comparing results from ip and oral exposures. Exposure by ip injection indeed produced marked hepatic and renal toxicity, but oral administration did not. The results suggest that ip injection of GCHF may induce secondary effects mediated by local toxicity rather than genotoxicity. Furthermore, these results continue to support the conclusion that glyphosate and GCHF are not genotoxic under exposure conditions that are relevant to animals and humans.

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Citations

Aug 13, 2009·Journal of Toxicology and Environmental Health. Part a·C BolognesiE J P Marshall
Jun 23, 2009·Toxicology·Céline GasnierGilles-Eric Séralini
Aug 19, 2015·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·R MesnageG E Séralini
Mar 14, 2013·Critical Reviews in Toxicology·Larry D Kier, David J Kirkland
Apr 30, 2009·Environmental and Molecular Mutagenesis·Marin MladinicDavor Zeljezic
Jun 27, 2021·Environmental Science and Pollution Research International·Fernanda de Maria SerraGisele Alborghetti Nai

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