Genotoxic potential of organic extracts from particle emissions of diesel and rapeseed oil powered engines

Toxicology Letters
Jan TopinkaMichal Vojtisek-Lom

Abstract

The present study was performed to identify possible genotoxicity induced by organic extracts from particulate matter in the exhaust of two typical diesel engines run on diesel fuel and neat heated fuel-grade rapeseed oil: a Cummins ISBe4 engine tested using the World Harmonized Steady State Test Cycle (WHSC) and modified Engine Steady Cycle (ESC) and a Zetor 1505 engine tested using the Non-Road Steady State Cycle (NRSC). In addition, biodiesel B-100 (neat methylester of rapeseed oil) was tested in the Cummins engine run on the modified ESC. Diluted exhaust was sampled with high-volume samplers on Teflon coated filters. Filters were extracted with dichlormethane (DCM) and DNA adduct levels induced by extractable organic matter (EOM) in an acellular assay of calf thymus DNA coupled with (32)P-postlabeling in the presence and absence of rat liver microsomal S9 fraction were employed. Simultaneously, the chemical analysis of 12 priority PAHs in EOM, including 7 carcinogenic PAHs (c-PAHs) was performed. The results suggest that diesel emissions contain substantially more total PAHs than rapeseed oil emissions (for the ESC) or that these concentrations were comparable (for the WHSC and NRSC), while c-PAHs levels were comparable (fo...Continue Reading

References

Oct 1, 1994·Environmental Health Perspectives·J L Mauderly
Dec 2, 2004·Mutation Research·Larry D ClaxtonSarah H Warren
Mar 22, 2007·Archives of Toxicology·Jürgen BüngerThomas Brüning
Mar 11, 2011·Journal of the Air & Waste Management Association·Michal Vojtisek-Lom

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Citations

Jul 19, 2013·BioMed Research International·Abderrahim NemmarErnesto Alfaro-Moreno
Oct 31, 2015·Inhalation Toxicology·Jeffrey A RossDavid M DeMarini
Oct 17, 2014·Environmental Science and Pollution Research International·Olga B PopovichevaJaroslav Schwarz
May 12, 2016·Archives of Toxicology·Sandro SteinerBarbara Rothen-Rutishauser
Sep 11, 2017·Environmental Science and Pollution Research International·Magdalena KowalskaAnna Lankoff
Sep 20, 2017·Critical Reviews in Food Science and Nutrition·Kumar GanesanBaojun Xu
Dec 12, 2017·Journal of Environmental Science and Health. Part A, Toxic/hazardous Substances & Environmental Engineering·Isabel C JaramilloKerry E Kelly
Jan 10, 2019·Particle and Fibre Toxicology·Liza SelleyIan Mudway

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