Genotoxic properties of representatives of alkylindazoles and aminoalkyl-indoles which are consumed as synthetic cannabinoids

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
Verena J KollerSiegfried Knasmüller

Abstract

Synthetic cannabinoids (SCs) cause similar effects as cannabis and are sold in herbal mixtures. Recent investigations indicate that some of these drugs possess genotoxic properties. Therefore, we tested representatives of two groups, namely, aminoalkylindoles (AM-2201 and UR-144) and 1-alkylindazoles (5F-AKB-48 and AM-2201-IC) in single cell gel electrophoresis and micronucleus (MN) assays with human lymphocytes and in Salmonella/microsome assays. All drugs except AM-2201 caused DNA-migration, the LOELs were between 50 and 75 µM. Furthermore, all SCs caused inhibition of cell division and significant induction of MN which reflect structural and numerical chromosomal aberrations. The LOEL values were 50 µM for UR-144 and 5-AKB-48 and 75 µM for the other drugs. Also the levels of nucleoplasmatic bridges which are formed from dicentric chromosomes were elevated under identical conditions while the frequencies of nuclear buds were not affected. These findings show that representatives of both groups cause chromosomal damage while the negative results in Salmonella assays (in strains TA98, TA100, TA1535, TA1537 and TA102) in absence and presence of metabolic activation indicate that they do not induce gene mutations. Taken together,...Continue Reading

References

May 1, 1983·Mutation Research·D M Maron, B N Ames
Mar 29, 2000·Environmental and Molecular Mutagenesis·R R TiceY F Sasaki
Dec 11, 2002·Mutagenesis·A HartmannUNKNOWN 4th International Comet Assay Workshop
Apr 26, 2003·Mutagenesis·Hannu Norppa, Ghita C-M Falck
Jun 5, 2007·Nature Protocols·Michael Fenech
Nov 27, 2007·Mutation Research·G IarmarcovaiT Orsière
Feb 4, 2009·Journal of Mass Spectrometry : JMS·Volker AuwärterNerea Ferreirós
Apr 2, 2009·Chemical & Pharmaceutical Bulletin·Nahoko UchiyamaYukihiro Goda
Feb 16, 2010·International Journal of Hygiene and Environmental Health·Paramjit GroverM F Rahman
Apr 10, 2010·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Jörg TeskeHans Dieter Tröger
Feb 15, 2011·Analytical and Bioanalytical Chemistry·Dariusz ZubaMartyna Maciow
Jul 12, 2011·Clinical Biochemistry·Hannah J PennJames H Nichols
May 9, 2012·Progress in Neuro-psychopharmacology & Biological Psychiatry·Kathryn A SeelyLiana Fattore
Oct 16, 2012·Forensic Science International : Synergy·Nahoko UchiyamaYukihiro Goda
Dec 10, 2013·Forensic Science International : Synergy·Piotr AdamowiczKarolina Sekuła
Apr 2, 2014·Toxicology and Applied Pharmacology·Verena J KollerSiegfried Knasmüller

❮ Previous
Next ❯

Citations

Feb 10, 2016·Archives of Toxicology·Franziska FerkSiegfried Knasmüller
Oct 21, 2015·Drug and Alcohol Dependence·Jolanta B Zawilska, Dariusz Andrzejczak
Feb 5, 2016·Journal of Molecular Neuroscience : MN·Jakub WojcieszakJolanta B Zawilska
May 11, 2016·Drug Testing and Analysis·Anca FrinculescuBram Miserez
Jul 16, 2016·MMWR. Morbidity and Mortality Weekly Report·Anne M RiedererUNKNOWN Toxicology Investigators Consortium (ToxIC)
Jan 15, 2017·The Journal of Pharmacology and Experimental Therapeutics·Brian F ThomasJenny L Wiley
Oct 31, 2019·Journal of Analytical Toxicology·Brandon C PresleySusan A Jansen-Varnum
Jun 9, 2020·Human & Experimental Toxicology·E M GulerA Kocyigit
Feb 14, 2020·International Journal of Molecular Sciences·Monia LenziMatteo Marti
Jul 3, 2021·International Journal of Molecular Sciences·Monia LenziPatrizia Hrelia

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antianginal Drugs: Mechanisms of Action

Antianginal drugs, including nitrates, beta-blockers, and calcium channel blockers, are used in the treatment of angina pectoris. Here is the latest research on their use and their mechanism of action.

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.

Related Papers

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
Luiz Carlos Santos PortoJaqueline Nascimento Picada
Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
Veronika A EhrlichSiegfried Knasmüller
© 2021 Meta ULC. All rights reserved