Genotoxic risk in health-care professionals occupationally exposed to low doses of ionizing radiation.

Toxicology and Industrial Health
Flávio Manoel Rodrigues da Silva-JúniorEdariane Menestrino Garcia

Abstract

The purpose of this study was to evaluate the potential influence of occupational ionizing radiation (IR) exposure on health professionals, assessing DNA damage using the comet and micronucleus (MN) assays and analyzing relative risks, correlations, and associated factors between outcomes and socioeconomic and lifestyle factors. Blood and buccal samples were collected from 36 workers, who actively participated in an imaging sector of a hospital, who were either exposed to IR directly or indirectly (9 internal control and 27 exposed), and 27 individuals living in the same city but with no occupational exposure (external control, unexposed/healthy). All radiation dosages performed on the 36 workers were less than 20 mSv/y, not exceeding the effective dose limit for occupational exposure. A questionnaire identified socioeconomic and lifestyle factors associated with the outcomes. The results of the MN assay showed a significant difference between both internal control and the exposed group when compared to the external control. For the comet assay, there were significant differences between the percent of tail DNA of the exposed group and external controls, but no difference was found between the exposed group and internal control...Continue Reading

References

Mar 1, 1988·Experimental Cell Research·N P SinghE L Schneider
Feb 1, 1995·Mutation Research·D W FairbairnK L O'Neill
Jul 1, 1994·International Journal of Radiation Biology·N P SinghE L Schneider
Feb 7, 2001·International Journal of Radiation Biology·P L Olive
Aug 24, 1999·Journal of Occupational and Environmental Medicine·U UndeğerN Başaran
Apr 18, 2000·Mutation Research·S Benhamou, A Sarasin
Jul 2, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Marcus S CookeJoseph Lunec
Jun 24, 2005·International Journal of Hygiene and Environmental Health·Nevenka Kopjar, Vera Garaj-Vrhovac
Jul 1, 2005·Breast Cancer Research : BCR·Goberdhan DimriVimla Band
Jun 26, 2007·Revista de saúde pública·Caroline Di Bernardi LuftAlexandro Andrade
Sep 18, 2007·Archives of Environmental & Occupational Health·Alba M GüerciAnalía I Seoane
Oct 6, 2007·Critical Reviews in Biochemistry and Molecular Biology·Rodrigo S GalhardoSusan M Rosenberg
Feb 8, 2008·Mutagenesis·Declan J McKennaValerie J McKelvey-Martin
Jun 17, 2008·Annals of the ICRP·Abel J GonzálezA Sugier
Dec 5, 2008·European Journal of Radiology·Farideh Zakeri, Tomohisa Hirobe
Oct 23, 2009·Nature·Stephen P Jackson, Jiri Bartek
Jun 30, 2010·Dose-response : a Publication of International Hormesis Society·Alexander M Vaiserman
Mar 31, 2012·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Kenny S CrumpJan M Zielinski
Jul 14, 2012·Journal of Toxicology and Environmental Health. Part a·Amina SaklyHassen Ben Cheikh
Apr 6, 2013·International Journal of Occupational Medicine and Environmental Health·Sana BouraouiAli Saad
Nov 26, 2013·Journal of Occupational and Environmental Medicine·Wenny BuitenhuisSusan Peters

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Citations

Nov 27, 2020·Toxicology and Industrial Health·Flavio Manoel Rodrigues da Silva JúniorEdariane Menestrino Garcia

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Methods Mentioned

BETA
X-ray
scraping
electrophoresis

Software Mentioned

Prism
ImageJ

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